Structure of (,)-4-bromo-2-{4-[4-bromo-1-(4-toluene-sulfon-yl)-1-pyrrol-2-yl]-1,3-di-nitro-butan-2-yl}-1-(4-toluene-sulfon-yl)-1-pyrrole, another ostensible by-product in the synthesis of -dimethyl hydro-dipyrrins.

The crystal structure of (,)-4-bromo-2-{4-[4-bromo-1-(4-toluene-sulfon-yl)-1-pyrrol-2-yl]-1,3-di-nitro-butan-2-yl}-1-(4-toluene-sulfon-yl)-1-pyrrole (, CHBrNOS) is presented. The title compound was isolated in suitable yield as a by-product in our synthesis of -dimethyl hydro-dipyrrins. We observe an unforeseen enanti-omeric resolution both in the bulk sample and the crystal of , with distinct C-H⋯O (C-H⋯O, C -H⋯O) inter-actions observed in the enanti-omers present, along with other inter-actions, namely C-H⋯O, forming a polymer along the crystallographic -axis direction.

Association of protective behaviors with SARS-CoV-2 infection: results from a longitudinal cohort study of adults in the San Francisco Bay Area.

Purpose: In an effort to decrease transmission during the first years of the COVID-19 pandemic, public health officials encouraged masking, social distancing, and working from home, and restricted travel. However, many studies of the effectiveness of these measures had significant methodologic limitations. In this analysis, we used data from the TrackCOVID study, a longitudinal cohort study of a population-based sample of 3846 adults in the San Francisco Bay Area, to evaluate the association between self-reported protective behaviors and incidence of SARS-CoV-2 infection.

Structures of -(pyridin-2-yl) 4-nitro-benzo-thio-ate, -(pyridin-2-yl) 4-methyl-benzo-thio-ate and -(pyridin-2-yl) 4-meth-oxy-benzo-thio-ate: building blocks for low-symmetry multifunctional tetra-pyrroles.

The crystal structures of three -(pyridin-2-yl) benzo-thio-esters with varying -phenyl substituents are presented, namely, -(pyridin-2-yl) 4-nitro-benzo-thio-ate (, CHNOS), -(pyridin-2-yl) 4-methyl-benzo-thio-ate (, CHNOS) and -(pyridin-2-yl) 4-meth-oxy-benzo-thio-ate (, CHNOS). This class of compounds are used in the mono-acyl-ation of pyrrolic species to yield multifunctional tetra-pyrroles. The structures presented herein are the first of their compound class.

ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD.

Objective: Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), is a severe pediatric disorder of uncertain etiology resulting in hypothalamic dysfunction and frequent sudden death. Frequent co-occurrence of neuroblastic tumors have fueled suspicion of an autoimmune paraneoplastic neurological syndrome (PNS); however, specific anti-neural autoantibodies, a hallmark of PNS, have not been identified. Our objective is to determine if an autoimmune paraneoplastic etiology underlies ROHHAD.

Incidence and Prevalence of Coronavirus Disease 2019 Within a Healthcare Worker Cohort During the First Year of the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic.

Background: Preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2_ infections in healthcare workers (HCWs) is critical for healthcare delivery. We aimed to estimate and characterize the prevalence and incidence of coronavirus disease 2019 (COVID-19) in a US HCW cohort and to identify risk factors associated with infection.

Methods: We conducted a longitudinal cohort study of HCWs at 3 Bay Area medical centers using serial surveys and SARS-CoV-2 viral and orthogonal serological testing, including measurement of neutralizing antibodies.