Publications by authors named "H A Risch"
Article Synopsis
- The American Cancer Society suggests that doctors should talk to women about endometrial cancer risks when they reach menopause, but more younger women under 50 are being diagnosed.
- A study looked at nearly 14,000 women with endometrial cancer and found that factors like body weight and diabetes increase the risk for both younger and older women.
- Educating women about these risk factors could help reduce the number of cases, as many endometrial cancer cases in both age groups are linked to these factors.
Article Synopsis
- The Article-in-Press has been withdrawn due to serious concerns raised by the scientific community regarding its citations, methodology, and conclusions.
- Despite the authors' submission of a revised manuscript, independent peer-reviewers found it did not adequately address the issues that led to the initial concerns.
- The authors dispute the withdrawal decision and the reasons behind it, indicating a disagreement with the journal’s actions.
Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.
Cancer Epidemiol Biomarkers Prev
September 2024
Article Synopsis
- - The study investigates how genetic variants affect the relationship between heavy alcohol consumption and the risk of pancreatic cancer, utilizing data from a sizable European ancestry population.
- - Researchers identified a new relevant genomic region (10p11.22) linked to pancreatic cancer risk and a specific SNP (rs7898449) that suggests this association is influenced by heavy alcohol consumption.
- - The findings highlight the potential role of the neuropilin 1 gene in pancreatic cancer development, offering new insights into cancer risk factors, especially among heavy drinkers.
Article Synopsis
- The study examined risk factors for epithelial ovarian cancer (EOC) among women of different racial and ethnic backgrounds, including Asian, Hispanic, Native Hawaiian/Pacific Islander, and White participants.
- Findings indicated that oral contraceptive (OC) use and childbirth (parity) were generally associated with lower EOC risk across all groups, especially in Native Hawaiian/Pacific Islander and Asian women.
- Significant differences in EOC risk factors were detected among the ethnic groups, suggesting that including more diverse populations in research could improve prevention strategies for ovarian cancer.
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10) and confirmed previously reported associations for 27 risk regions. Conditional analyses identified an additional 11 signals independent of the primary signal at six risk regions (p value <10).
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