Publications by authors named "H A Remmer"
Quiescent prostate cancer (PCa) cells are common in tumors but are often resistant to chemotherapy. Quiescent PCa cells are also enriched for a stem-like tumor initiating population, and can lead to recurrence after dormancy. Unfortunately, quiescent PCa cells are difficult to identify and / or target with treatment in part because the relevant markers are intracellular and regulated by protein stability.
View Article and Find Full Text PDFObjective: Despite obesity's significant impact on reproduction, its influence on the physiology of the human endometrium is largely understudied. We hypothesized that endometrial proteomic differences exist between obese (OW; body mass index [BMI] ≥30 kg/m) and normal-weight women (NWW; BMI, 18.5-24.
View Article and Find Full Text PDFAging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm.
Arterioscler Thromb Vasc Biol
August 2022
Article Synopsis
- Aging negatively impacts the human aorta, with differences in protein expression and biological processes observed in healthy and thoracic aortic aneurysms (TAA) across age groups.
- Proteomics showed that young aortas focus on immune processes, while older aortas shift towards metabolic processes, indicating age-related changes in aortic health.
- Results highlight the need for age-specific approaches in developing therapies for vascular diseases like TAA, as proteins involved in inflammation and mitophagy are affected differently based on age and health condition.
The identification of antibody variable regions in the heavy (VH) and light (VL) chains from hybridomas is necessary for the production of recombinant, sequence-defined monoclonal antibodies (mAbs) and antibody derivatives. This process has received renewed attention in light of recent reports of hybridomas having unintended specificities due to the production of non-antigen specific heavy and/or light chains for the intended antigen. Here we report a surprising finding and potential pitfall in variable domain sequencing of an anti-human CD63 hybridoma.
View Article and Find Full Text PDFArticle Synopsis
- Trauma is the main cause of death in young individuals, often leading to kidney injury that raises mortality risk; valproic acid (VPA) has shown promise in improving survival in trauma cases.* -
- Two experimental models on swine demonstrated that VPA significantly improved survival rates and reduced serum creatinine levels, which indicate kidney injury, compared to controls.* -
- The study concludes that a single dose of VPA (150 mg/kg) effectively protects against acute kidney injury in swine models experiencing severe trauma and blood loss.*