Publications by authors named "H A Metwaly"
Article Synopsis
- Pharmacogenomics (PGx) links genetic differences to drug responses, aiming to enhance treatment outcomes and minimize side effects, but it's underutilized in developing countries.
- Surveys conducted in Egypt and Lebanon revealed limited availability of PGx testing in healthcare facilities, with Egypt having some testing and Lebanon offering almost none.
- There is significant interest among pharmacists (over 34%) and physicians (almost 25%) in learning about PGx, with a consensus on the necessity for educational programs to improve PGx implementation in the Middle East.
The existing treatise targeted to compare the effects of adding different nano-emulsions essential oils (olive, flaxseed, and grapeseed oils) in freezing extender on semen quality and freezability in buffalo. Nano-emulsions were prepared from olive, flaxseed, and grapeseed oils and characterized for their sizes and shapes. Semen extended in four tubes were supplemented with 0 (control) and 3.
View Article and Find Full Text PDFThe ongoing development of novel drugs for breast cancer aims to improve therapeutic outcomes, reduce toxicities, and mitigate resistance to chemotherapeutic agents. Doxorubicin (Dox) is known for its significant side effects caused by non-specific cytotoxicity. In this study, we investigated the antitumor activity of galloylquinic acids (BF) and the beneficial role of their combination with Dox in an Ehrlich ascites carcinoma (EAC)-bearing mouse model, as well as their cytotoxic effect on MCF-7 cells.
View Article and Find Full Text PDFAims: This study aims to investigate the potential synergistic effect of the combined treatment of galloylquinic acid compounds from Copaifera lucens with doxorubicin via the modulation of the Notch pathway in solid Ehrlich carcinoma-bearing mice model.
Main Methods: The solid tumor model was induced by subcutaneous inoculation of Ehrlich carcinoma cells in the right hind limb of mice, after serial syngeneic cell passages in the peritoneal cavity. Sixty mice were allocated into five groups including treated groups with galloylquinic acid compounds, doxorubicin, and their combination.