Publications by authors named "H A Kindon"
In T-maze tests given to gonadectomized ferrets treated daily with estradiol benzoate (EB), females consistently prefer to approach and interact sexually with a stud male whereas male subjects, on average, prefer an estrous female. In the present experiment this sexually allomorphic pattern of partner preference was changed in males given lesions of the medial preoptic area/anterior hypothalamus (mPOA/AH). Electrolytic lesions, which caused extensive bilateral damage to the mPOA/AH, including the sexually dimorphic male nucleus (MN) of the POA/AH, led males to shift their mean preference away from the estrous female to the stud male.
View Article and Find Full Text PDFBackground & Aims: Goblet cells secrete a combination of trefoil peptides and mucin glycoproteins to form a continuous gel on the mucosal surface. The functional effects of these products remain uncertain.
Methods: Trefoil peptides and/or mucin glycoproteins were added to Transwell monolayers of the human colonic cancer-derived T84 cell line.
Article Synopsis
- Trefoil peptides are protease-resistant peptides found in the gastrointestinal tract, hypothesized to act as growth factors, but their functional properties remain mostly unknown.
- When tested on various cell lines, these peptides did not significantly impact cell proliferation, but they markedly increased the migration rate of epithelial cells in a wound healing model, especially when combined with mucin glycoproteins.
- Unlike cytokines that affect intestinal epithelial restitution via TGF-beta, trefoil peptides appear to facilitate mucosal healing through mechanisms that don't involve changes in TGF-beta levels.