Publications by authors named "H A Hey"
Background: Decision-making in lumbar surgery for degenerative conditions is influenced by various factors, including patient expectations and empowerment. The role of patient-reported outcomes (PROs) in guiding these decisions is underexplored. This study aims to understand the perspectives of patients and spine surgeons in decision-making for lumbar surgery and explore their perspectives on the relevance and influence of pre- and post-surgery PROs.
View Article and Find Full Text PDFStudy Design: Cross-sectional Cohort Study.
Objective: To determine the cervicothoracic inflection point in an asymptomatic, adult population.
Introduction: The cervicothoracic inflection point (CTIP) is an important sagittal marker to understand for patients with cervical deformities.
Spinal fusion, a common surgery performed for degenerative lumbar conditions, often uses recombinant human bone morphogenetic protein 2 (rhBMP-2) that is associated with adverse effects. Mesenchymal stromal/stem cells (MSCs) and their extracellular vesicles (EVs), particularly exosomes, have demonstrated efficacy in bone and cartilage repair. However, the efficacy of MSC exosomes in spinal fusion remains to be ascertained.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how matrix metalloproteinase-2 (MMP-2) contributes to ligamentum flavum (LF) hypertrophy in a rat model and assessed the effects of elastin-derived peptides (EDPs) on MMP-2 and tissue inhibitors (TIMPs) in LF cells.
- - After inducing mechanical stress through surgery, researchers observed significant changes in LF structure, including increased thickness and cellular changes, alongside elevated MMP-2 and TIMP levels after 6 and 12 weeks.
- - EDPs were found to suppress MMP-2 expression and alter TIMP levels in isolated rat LF cells, highlighting a complex interaction where EDPs enhance the MMP-2/TIMPs