Publications by authors named "H A Heij"
Article Synopsis
- Appendicitis is a common issue leading to surgery in kids, with differing levels of severity (simple vs. complex) that aren't fully understood, particularly regarding T cell responses.
- Research involved collecting samples from 20 children to analyze T cells and appendiceal microbiota through flow cytometry.
- Results showed that complex appendicitis had more highly differentiated T cells and changes in cytokine production, indicating disrupted immune responses and alterations in gut bacteria compared to simple appendicitis, suggesting a link between T cell dysregulation and microbiota changes.
Currently, accurate biomarkers differentiating simple (phlegmonous) from complex (gangrenous and/or perforated) appendicitis in children are lacking. However, both types may potentially require different treatment strategies, and the search for diagnostic modalities remains warranted. Previously, we demonstrated a distinct microbiota (both an increased bacterial diversity and abundance) in the appendix of children with complex compared to simple appendicitis.
View Article and Find Full Text PDFLong-term results after non-operative treatment for children with simple appendicitis seem promising, possibly avoiding appendicectomy in 70 per cent of children after a median follow-up of 5 years. The need for delayed appendicectomy more than 2 years after the initial treatment is rare (0–5 per cent) and no complications occurred past 1 year, including children who underwent delayed appendicectomy.
View Article and Find Full Text PDFPurpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.
Results (methods And Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.
Background: Two types of appendicitis are hypothesized, simple and complex, with potential different treatment strategies. To improve differentiation, underlying pathogeneses need to be further unraveled.
Aim: To determine if the microbial composition in the appendix differs between children with simple and complex appendicitis.