Publications by authors named "H A Gelbard"
Article Synopsis
- Microglia are special cells in the brain that help fight infections, and they can cause problems in diseases like Alzheimer's and after COVID-19 infection.
- When someone gets COVID-19, it can cause inflammation in the brain, leading to long-term effects called post-acute sequelae of COVID-19 (PASC).
- Scientists are studying how certain proteins like MLK3 and LRRK2 affect inflammation, which could help treat both PASC and neurocognitive issues related to HIV.
Various oligomeric species of amyloid-beta have been proposed to play different immunogenic roles in the cellular pathology of Alzheimer's Disease. The dynamic interconversion between various amyloid oligomers and fibrillar assemblies makes it difficult to elucidate the role each potential aggregation state may play in driving neuroinflammatory and neurodegenerative pathology. The ability to identify the amyloid species that are key and essential drivers of these pathological hallmarks of Alzheimer's Disease is of fundamental importance for also understanding downstream events including tauopathies that mediate neuroinflammation with neurologic deficits.
View Article and Find Full Text PDFObjective: To determine the long-term outcomes, including mortality and recurrent seizures, among children living with HIV (CLWH) who present with new onset seizure.
Methods: Zambian CLWH and new onset seizure were enrolled prospectively to determine the risk of and risk factors for recurrent seizures. Demographic data, clinical profiles, index seizure etiology, and 30-day mortality outcomes were previously reported.