Publications by authors named "H A Garcia-Perdomo"
Article Synopsis
- The study aimed to explore how a specific metabolomic profile can help diagnose localized prostate cancer by examining various biological samples.
- Researchers analyzed a total of 1248 studies, narrowing down to 14 case-control studies that primarily focused on serum metabolite analysis, revealing significant associations with certain metabolites.
- The findings indicated that disruptions in the metabolism of fatty acids, amino acids, nucleotides, and steroid hormones are linked to localized prostate cancer, with notable increases in amino acids like glutamate and aspartic acid, and decreases in glycine and serine.
Article Synopsis
- The penis is a significant symbol of identity and masculinity for Western men, and its loss can lead to serious psychological and social issues.
- Penile cancer, although rare, often results in penectomy (removal of the penis), which deeply affects survivors, leading to increased rates of depression, anxiety, and a distorted sense of masculinity.
- New masculinities theory suggests a need to redefine masculinity beyond physical attributes, offering potential psychological support and improving the quality of life for those affected by penile cancer.
Urological cancers represent 13.1% of cancer cases in the world, with a mean age of diagnosis of 67 years, making it a geriatric disease. The lack of participation and evaluation of treatments by the geriatric oncologic population has made their mortality rate higher than that of other oncologic population groups, urologic cancers being no exception.
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- The study aimed to identify factors linked to the recurrence of urethral stricture in patients who underwent internal urethrotomy.
- A systematic review was conducted, analyzing 402 studies but ultimately including 6 clinical trials involving 1,723 patients with urethral stricture.
- The main finding was that the length of urethral stricture was the strongest predictor of recurrence, with additional factors including the cause of the stricture, previous treatments, and low urine flow rates.
Article Synopsis
- - The study aimed to evaluate the safety and effectiveness of mirabegron for treating urinary symptoms in children with refractory overactive bladder (OAB).
- - A systematic review was conducted using multiple medical databases, assessing only studies that included children and adolescents using mirabegron without a control group, with findings showing high rates of improvement and safety.
- - The conclusions suggest that mirabegron is a promising alternative treatment for children with refractory OAB, especially for those who cannot tolerate traditional antimuscarinic medications.