Publications by authors named "H A Ebrahim"
Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive phenotype of prostate cancer (PC). Tryptophan oxidative catabolism by indoleamine 2,3-dioxygenase-1 (IDO1) cleaves the indole ring to kynurenine (Kyn), an endogenous ligand for the aryl hydrocarbon receptor (AhR), which activates multiple tumorigenesis pathways. The IDO1-Kyn-AhR axis is aberrantly dysregulated in mCRPC.
View Article and Find Full Text PDFInflammatory biomarkers like C-reactive protein (CRP) are elevated in a subset of patients with depression and associated with lower functional connectivity (FC) in a ventral striatum (VS) to ventromedial prefrontal cortex (vmPFC) reward circuit and symptoms of anhedonia. Evidence linking these relationships to the effects of inflammation on dopamine is consistent with our recent findings that acute levodopa (L-DOPA) increased VS-vmPFC FC in association with deceased anhedonia in depressed patients with higher but not lower CRP (>2 versus ≤ 2 mg/L). To determine whether repeated L-DOPA administration caused sustained effects on FC and behavior in these patients, medically stable depressed outpatients with CRP > 2 mg/L and anhedonia (n = 18) received one week of three doses of L-DOPA (150-450 mg/day/week with carbidopa) or placebo in a randomized order.
View Article and Find Full Text PDFIntroduction: Statins are frequently prescribed to lower the risk of atherosclerosis and cardiovascular-related diseases. While statins are considered safe, there are occasional accidental overdoses in children that warrant concern for how to protect children from unintended consumption. We aimed to determine which statins were more prone to injury, characterize the injury types commonly seen for each statin, assess the age at which statin-related injuries were most frequent, and compare statin-related injuries among genders.
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- Despite the high number of sheep in Ethiopia, their productivity is low due to poor-quality feed, prompting a systematic review to analyze the impact of dietary supplements on growth performance and carcass yield.
- The study incorporated data from 21 previous studies involving 533 indigenous sheep and found that dietary supplements significantly improved various performance metrics, including body weight and feed efficiency.
- Results indicated that different breeds responded variably to supplements, with legumes providing the most substantial benefits, particularly for Afar, Arsi Bale, and Washera sheep.
Article Synopsis
- Leprosy is a significant public health issue in Ethiopia, causing social stigma and poor quality of life, emphasizing the need for collaborative actions to address its impact in endemic regions.
- A cross-sectional study involving 256 leprosy-suspected cases was conducted to assess the acid-fast positivity rate and identify factors contributing to the disease, using interviews and laboratory testing.
- The study found a 19.6% positivity rate for leprosy, with significant contributing factors including being male, living in rural areas, poor diet, inadequate hygiene, and co-infections.