Publications by authors named "H A E Asfour"
The clinical use of 5-fluorouracil (5-FU) in cancer patients has been associated with nephrotoxicity, which is greatly curbing its therapeutic application. The pathogenesis of 5-FU-induced nephrotoxicity is complex; however, oxidative stress-mediated inflammation is considered a central pathogenic factor. Urolithin B (UB), a product of ellagitannins, has recently been assigned diverse pharmacological activities due to its potent antioxidant and anti-inflammatory properties.
View Article and Find Full Text PDFArticle Synopsis
- Embryo transfer (ET) is being tested in horses to enhance genetic improvement and the study focuses on improving ET success by re-flushing and re-transferring embryos from contaminated to healthy recipient mares.
- The research involved 25 recipient mares, examining the effectiveness of embryo transfer, with 7 serving as a control group and 18 undergoing treatment to check for infections before transferring embryos.
- Results showed high rates of endometritis in control mares, leading to embryonic death, while treated mares had a better pregnancy rate, especially in embryos with well-developed capsules, highlighting the importance of monitoring and addressing uterine health.
Article Synopsis
- Resistance to antibiotics is a serious health issue that needs quick solutions, and using anti-virulence agents like cilostazol may be a good strategy.*
- Cilostazol, a drug already used for other health problems, was tested to see if it could help stop harmful bacteria, like Pseudomonas aeruginosa, from causing infections.*
- The study found that cilostazol could reduce the bacteria's ability to form harmful groups and damage organs, and it worked well together with antibiotics, which could help fight infections better without leading to more resistance.*
Intrahepatic cholestasis is a common clinical form of hepatobiliary injury characterized by the intrahepatic accumulation of toxic bile acids. Besides its antidiabetic activity, the dipeptidyl peptidase IV inhibitor sitagliptin (SG) has been recently assigned diverse pharmacological activities and therapeutic potential against different disorders owing to its emerging antioxidant and anti-inflammatory properties. The current study explored the potential hepatoprotective effect of SG on α-naphthyl isothiocyanate (ANIT)-induced cholestatic liver injury (CLI) in mice and investigate its possible targeted signaling pathways.
View Article and Find Full Text PDFArticle Synopsis
- Cholestasis is a liver disorder caused by the buildup of toxic bile acids, leading to liver damage and inflammation, with few treatment options available, highlighting the need for new therapies.
- The study investigates the effects of Pirfenidone (PF), a drug known for treating lung fibrosis, in a mouse model of cholestatic liver injury induced by ANIT, finding that PF significantly reduces harmful liver enzymes and improves liver tissue damage.
- PF’s protective effects are linked to its ability to regulate key signaling pathways related to bile acid transport, inflammation, and oxidative stress, suggesting its potential as a therapeutic option for cholestasis-related liver injuries.