Molecular Characterization and Potential Inhibitors Prediction of Protein Arginine Methyltransferase-2 in Carcinoma: An Insight from Molecular Docking, ADMET Profiling and Molecular Dynamics Simulation Studies.

Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.

Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.

Unveiling the role of sintering temperatures in the physical properties of Cu-Mg ferrite nanoparticles for photocatalytic application.

This research presents an explicit analysis of the effects of sintering temperature (T) on the structural, morphological, magnetic, and optical properties of CuMgFeO nanoferrites synthesized via the sol-gel method. To accomplish it, Cu-Mg ferrite NPs were sintered at temperatures ranging from 300 to 800 °C in increments of 100 with a constant holding duration of 5 h. Thermogravimetric analysis was used to observe the degradation of organic components and the thermally stable zone of the material.

Leveraging generative neural networks for accurate, diverse, and robust nanoparticle design.

Tandem neural networks for inverse design can only make single predictions, which limits the diversity of predicted structures. Here, we use conditional variational autoencoder (cVAE) for the inverse design of core-shell nanoparticles. cVAE is a type of generative neural network that generates multiple valid solutions for the same input condition.

Experimental analysis of a solar air heater using waste mild steel chips as a sensible heat storage material.

Heat storage materials improve the utility of solar air heaters (SAHs) after sunset. This study investigates an improved solar air heater (SAH) performance with baffles and waste mild steel chips as sensible heat storage (SHS) materials. Comparative experimental natural convection heat transfer studies were performed with four different improved air heater setups under similar solar radiation conditions.