[Analysis of clinical features and prognostic factors of focal cerebral arteriopathy in children].

To summarize the clinical characteristics of focal cerebral arteriopathy (FCA) in children, and to analyze its influencing factor of prognosis. A retrospective cohort study was conducted. Clinical data from 40 children with FCA who were hospitalized at the Department of Neurology, Beijing Children's Hospital, Capital Medical University, from September 2015 to August 2024 were collected.

Data on insect biodiversity in a Chinese potato agroecosystem from DNA metabarcoding.

Potato (Solanum tuberosum) is a staple crop important in global food security. As a leading potato producer, China faces significant challenges from insect pest infestations that compromise yield and quality. However, insect communities within Chinese potato fields remain poorly characterized.

Antifouling and Bactericidal Zwitterionic Polymer Coatings with Synergistic Inhibitory and Killing Properties.

Polymeric coatings that combine resistance to adhesion ("defending") and killing ("attacking") of biocontaminants were proposed to endow the surface with nonadhesive and bactericidal capabilities. In contrast, a zwitterionic copolymer P(GMA--DMAPS) with antifouling groups ([2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide, DMAPS) and a zwitterionic/cationic copolymer P(GMA--DMAPS--DMC) with bactericidal groups ([2-(methacryloyloxy)ethyl]trimethylammonium chloride, DMC) were synthesized, of which the latter exhibited synergistic inhibitory and killing properties. The distinct feed ratios of monomers were conducted, and the optimal molar ratio was obtained.

Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu Decoction.

Ethnopharmacological Relevance: The Xianlian Jiedu Decoction (XLJDD), a traditional Chinese medicine (TCM) decoction, which is effective in clinical treatment of colorectal cancer (CRC). Nevertheless, the pharmacodynamic material basis and mechanism of its action have not been explored yet.

Aims Of The Study: To investigate the potential functional components and possible mechanism of XLJDD in anti-CRC.

Non-viral, high throughput genetic engineering of primary immune cells using nanostraw-mediated transfection.

Transfection of proteins, mRNA, and chimeric antigen receptor (CAR) transgenes into immune cells remains a critical bottleneck in cell manufacturing. Current methods, such as viruses and bulk electroporation, are hampered by low transfection efficiency, unintended transgene integration, and significant cell perturbation. The Nanostraw Electro-actuated Transfection (NExT) technology offers a solution by using high aspect-ratio nanostraws and localized electric fields to precisely deliver biomolecules into cells with minimal disruption.