Proximity Ligation Assay to Detect the Proximity Between Host Proteins and Viral Proteins of HIV-1.

The study of host-pathogen interaction often requires interrogating the protein-protein interactions and examining post-translational modifications of the proteins. Traditional protein detection strategies are limited in their sensitivity, specificity, and multiplexing capabilities. The Proximity Ligation Assay (PLA), a versatile and powerful molecular technique, can overcome these limitations.

Impact of hyperthyroidism and its treatment on the outcome of mental health, occupational functioning, and quality of life: A naturalistic, prospective study.

Context Background: Hyperthyroidism has a major impact on mental health.

Aims: We intended to determine the magnitude of the unmet need for mental health support in patients with hyperthyroidism attending an endocrinology clinic.

Settings And Design: General Hospital Endocrine Department, Prospective Study.

Diagnostic utility of C-methionine PET/CT in primary hyperparathyroidism in a UK cohort: A single-centre experience and literature review.

Objective: Primary hyperparathyroidism is a common endocrine disorder, with 80% of all cases usually caused by one single hyperfunctioning parathyroid adenoma. Conventional imaging modalities for the diagnostic work-up of primary hyperparathyroidism (PHPT) include ultrasound of the neck, 99mTc-sestamibi scintigraphy, and four-dimensional computed tomography (4D-CT). However, the role of other imaging modalities, such as 11C-methionine PET/CT, in the care pathway for PHPT is currently unclear.

The novel HLA-C*12:365 allele identified in a Gujarati individual from India.

The novel HLA-C allele HLA-C*12:365 identified in an individual from the Gujarati population.

Genomic sequence of the HLA-A*02:01:209 allele identified in a solid organ recipient.

The novel HLA-A allele HLA-A*02:01:209 sequence identified in a solid organ recipient.