Publications by authors named "H A Briele"

Purpose: To determine in a randomized prospective multi-institutional trial whether the addition of tumor necrosis factor alpha (TNF-alpha) to a melphalan-based hyperthermic isolated limb perfusion (HILP) treatment would improve the complete response rate for locally advanced extremity melanoma.

Patients And Methods: Patients with locally advanced extremity melanoma were randomly assigned to receive melphalan or melphalan plus TNF-alpha during standard HILP. Patient randomization was stratified according to disease/treatment status and regional nodal disease status.

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Objectives: To determine whether economically disadvantaged urban women with locally advanced breast cancer (American Joint Committee on Cancer stages IIB to IIIB) have rates of response to sequential neoadjuvant chemotherapy and radiation, breast salvage rates, overall survival rates, and disease-free survival rates comparable with those previously reported in other socioeconomic groups and to compare these variables in different ethnic groups within the study population.

Design: Prospective, nonrandomized, case series.

Setting: Urban county hospital.

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Article Synopsis
  • The study focused on fifteen women diagnosed with genital malignant melanoma, ranging in age from 19 to 66 years, with the majority being white.
  • It was found that 66.6% of the patients died from the disease, with survival times varying significantly, and the predominant type of melanoma was superficial spreading melanoma (50%).
  • The research utilized special methods to assess tumor invasion levels, revealing that no lesions were classified as in situ, and the thickness of tumors varied, correlating with patient survival outcomes.
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Whether the prognosis for black women with breast cancer differs from that of nonblack women remains controversial. The treatment results of 526 black women who received definitive therapy for Stage I-III breast cancer at Cook County Hospital, 1973 through 1987 are presented. The 5-year and 10-year projected survival rates for 272 node-negative patients (83.

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