Publications by authors named "H A Berger"
Down syndrome is a chromosomal condition occurring in about 220,000 individuals in the United States. Previous research showed almost 1 in 5 individuals with Down syndrome in the U.S.
View Article and Find Full Text PDFOrganisms are repeatedly exposed to fluctuating environmental and nutritional conditions. Transcriptional memory has been shown to be a mechanism to cope with these fluctuations because it increases the speed and the magnitude of the cellular response to a certain re-occurring condition and therefore optimizes adaptation and fitness in a given environment. We found that genes coding for sterigmatocystin (ST) production in Aspergillus nidulans are activated stronger when cells are repeatedly exposed to nutrient starvation, compared to cells that experience this condition for the first time.
View Article and Find Full Text PDFInteraction between electrons and phonons in solids is a key effect defining the physical properties of materials, such as electrical and thermal conductivity. In transition metal dichalcogenides (TMDCs), the electron-phonon coupling results in the formation of polarons, quasiparticles that manifest themselves as discrete features in the electronic spectral function. In this study, we report the formation of polarons at the alkali-dosed MoSe surface, where Rashba-like spin splitting of the conduction band states is caused by an inversion-symmetry breaking electric field.
View Article and Find Full Text PDFArticle Synopsis
- - Fungal diseases caused by *Fusarium oxysporum* lead to significant agricultural losses, and controlling these pathogens is challenging due to limited understanding of their nutrient acquisition during host colonization.
- - The study identifies the transcriptional regulator Mac1 as crucial for copper acquisition in *F. oxysporum*, influencing its growth and ability to infect host plants like tomatoes and other organisms.
- - By discovering that overexpressing specific copper-related genes can restore pathogenicity in a mac1 mutant, this research opens new avenues for developing strategies to protect crops from fungal infections.
Article Synopsis
- - Cells without p53 signaling are common in ulcerative colitis (UC) and play a key role in the development of colorectal cancer linked to UC.
- - Epithelial injury during colitis triggers stem cells to shift to a "fetal-like" regenerative state, which is regulated by p53 signaling during colitis but not during normal conditions.
- - The study shows that while p53 is crucial in stopping excessive regeneration in healthy cells during injury, cells lacking p53 continue proliferating due to altered glycolysis processes, which helps explain their prevalence in UC and related cancers.