Red-Emitting Pyrrolyl Squaraine Molecular Rotor Reports Variations of Plasma Membrane and Vesicular Viscosity in Fluorescence Lifetime Imaging.

The viscosity that ensures the controlled diffusion of biomolecules in cells is a crucial biophysical parameter. Consequently, fluorescent probes capable of reporting viscosity variations are valuable tools in bioimaging. In this field, red-shifted probes are essential, as the widely used and gold standard probe remains green-emitting molecular rotors based on BODIPY.

The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7.

The human immunodeficiency virus-1 (HIV-1) nucleocapsid protein (NCp7) is a nucleic acid chaperone protein with two highly conserved zinc fingers. To exert its key roles in the viral cycle, NCp7 interacts with several host proteins. Among them, the human NoL12 protein (hNoL12) was previously identified in genome wide screens as a potential partner of NCp7.

Lysosomes Targeting pH Activable Imaging-Guided Photodynamic Agents.

Photodynamic therapy (PDT) is a photochemistry-based medical treatment combining light at a specific wavelength and a photosensitizer (PS) in the presence of oxygen. Application of PDT as a conventional treatment is limited and clearly the approval in clinics of new PS is challenging. The selective accumulation of the PS in the targeted malignant cells is of paramount importance to reduce the side effects that are typical of the current worldwide approved PS.

Updated insight into the characterization of nano-emulsions.

Introduction: In most of the studies, nano-emulsion characterization is limited to their size distribution and zeta potential. In this review, we present an updated insight of the characterization methods of nano-emulsions, including new or unconventional experimental approaches to explore in depth the nano-emulsion properties.

Area Covered: We propose an overview of all the main techniques used to characterize nano-emulsions, including the most classical ones, up to and evaluation.

Mechanical Characteristics Evaluation of a Single Ply and Multi-Ply Carbon Fiber-Reinforced Plastic Subjected to Tensile and Bending Loads.

Carbon fiber-reinforced composites represent a broadly utilized class of materials in aeronautical applications, due to their high-performance capability. The studied CFRP is manufactured from a 3K carbon biaxial fabric 0°/90° with high tensile resistance, reinforced with high-performance thermoset molding epoxy vinyl ester resin. The macroscale experimental characterization has constituted the subject of various studies, with the scope of assessing overall structural performance.