N-acetyl aspartate levels early after ischemic stroke accurately reflect long-term brain damage.

Background: Estimation of brain damage following an ischemic stroke is most often performed within the first few days after the insult, where large amounts of oedematous fluid have accumulated. This can potentially hamper correct measurement of infarcted area, since oedema formation poorly reflects infarct size. This study presents a non-invasive, easily applicable and reliable method to accurately predict long-term evolution and late-stage infarction.

Proteome-wide profiling and mapping of post translational modifications in human hearts.

Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins. PTMs contribute to regulation of protein function and thereby greatly increase the functional diversity of the proteome. In the heart, a few well-studied PTMs, such as phosphorylation and glycosylation, are known to play essential roles for cardiac function.

Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response.

Background: Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of irradiated cancerous tissue will lead to an increase in quantitative apparent diffusion coefficient (ADC) values. DW-MRI can therefore serve as a non-invasive marker of cell death and apoptosis in response to treatment.

Solid-state emissive O-BODIPY dyes with bimodal emissions across red and near infrared region.

Fluorescent compounds with solid-state emission are expected to have broad applications in the development of optoelectronic devices. In this study, we develop O-BODIPY based fluorescent dyes which exhibit strong bimodal solid-state emissions across red and NIR regions. After one pot synthesis, samples are characterized by X-ray diffraction, cyclic voltammetry, UV-vis absorption, and fluorescence spectra.

Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions.

Unlabelled: We have developed a I-radiolabeled injectable fiducial tissue marker with the potential to replace current methods used for surgical guidance of non-palpable breast tumors. Methods in routine clinical use today such as radioactive seed localization, radio-guided occult lesion localization and wire-guided localization suffers from limitations that this injectable fiducial tissue marker offers solutions to. The developed I-radiolabeled injectable fiducial tissue marker is based on highly viscous sucrose acetate isobutyrate.