Publications by authors named "H -U Wilms"
Article Synopsis
- - The study addresses the issue of limited ancestral diversity in genome-wide association studies (GWAS), which makes it hard to find genetic risk variants in non-European ancestry groups, focusing on Alzheimer's Disease (AD).
- - Researchers analyzed a multi-ancestry GWAS dataset within the Alzheimer's Disease Genetics Consortium (ADGC) involving individuals from various ancestries, identifying 13 shared risk loci and 3 ancestry-specific loci, highlighting the benefits of diverse samples.
- - The findings underscore the importance of including underrepresented populations in genetic research, suggesting that even smaller sample sizes can lead to the discovery of novel genetic variants related to AD and implicating specific biological pathways like amyloid regulation and neuronal development.
Article Synopsis
- Selective loss of inhibitory interneurons (INs) in the subiculum may lead to increased excitatory activity, potentially triggering epileptic seizures, particularly in mesial temporal lobe epilepsy (MTLE).
- Research using a kainate mouse model revealed significant cell loss in the subiculum along with changes in IN subpopulations, particularly a 50% reduction in parvalbumin (PV) and calretinin (CR) expressing INs.
- Although there was an increase in neuropeptide Y (NPY) positive neurons, the increase was attributed to non-GABAergic neurons rather than a rise in NPY-expressing INs, indicating a unique vulnerability among these cells in MTLE.
Influenza virus infection is a rare cause of neurological complications, with acute necrotizing encephalopathy (ANE) being among the deadliest. Due to the low incidence of ANE, literature about its association with influenza B infection is limited. We present the case of a 29-year-old previously healthy man with an imaging and clinical diagnosis of influenza B virus infection and sudden decline in mental status.
View Article and Find Full Text PDFImpulse control disorder (ICD) has been linked to dopamine agonist use in patients with Parkinson's disease. Increased creativity is another cognitive side effect of dopaminergic therapy. While ICD is well recognized in the literature, enhanced creativity as a positive phenomenon is underreported because it does not negatively affect the patients' quality of life.
View Article and Find Full Text PDFThe coconut palm or "tree of life" is one of nature's most useful plants and the demand for its fruit is increasing. However, coconut production is threatened by ageing plantations, pests and diseases. Currently, the palm is exclusively propagated via seeds, limiting the amount of planting material.
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