The game of language learning and rewiring biocognitive receptors.

This study introduces a framework that integrates AI-driven Game-Based Language Teaching (GBLT) with advanced neuroscience to transform language education for visually impaired learners. Built on the principles of neuroplasticity and epigenetics, the approach leverages educational psychology with the help of adaptive AI to deliver personalized, gamified learning experiences that reshape neural pathways, improve memory retention, and strengthen emotional resilience. By fostering low-stress, immersive environments, it triggers positive epigenetic changes, enhancing long-term cognitive flexibility.

Mental and Oral Health: A Dual Frontier in Healthcare Integration and Prevention.

Mental and oral health are interrelated, and problems in one area usually affect the other. This review discusses the complex relationships between oral and mental health, particularly the psychosocial challenges faced by individuals with mental health disorders in maintaining oral hygiene, including stigma, lack of access to care, and financial barriers. It also discusses how psychiatric conditions influence oral health, with regard to issues such as dry mouth, gum disease, and tooth decay, and how poor oral health can aggravate mental well-being.

A Rare Case Report of Listeria ivanovii Bacteremia in an Elderly Patient with Uncontrolled Diabetes and Chronic Kidney Disease from South India.

We report a rare case of Listeria ivanovii in elderly immunocompromised man with chronic kidney disease from South India, which was identified by conventional methods as well as MALDI-TOF and confirmed with 16S rRNA sequencing. In addition, literature search was done and the 10 cases of Listeria ivanovii infections reported earlier were discussed.

Non-pharmacological Radical Methods for Treating Postpartum Depression Around the Globe: A Narrative Review.

Mental health conditions during pregnancy, especially postpartum depression (PPD), can have profound and long-lasting effects on the individual, impeding her ability to bond with her child and disrupting the family dynamics. Although pharmacological treatments like antidepressants are the mainstay treatment options, several mothers have concerns about their safety and potential side effects, especially breastfeeding mothers. There is an emerging interest in exploring the use of non-pharmacological interventions as an alternative treatment modality for PPD.

Exploring predementia: Understanding the characteristics of subjective cognitive decline plus from India.

Background: Subjective cognitive decline (SCD) is the early predementia syndrome. that occurs even before the development of objective cognitive decline. SCD plus refers to an additional set of criteria that increases the likelihood of developing mild cognitive impairment and further progressing to Alzheimer's disease (AD).

An Interesting Case of Vitamin D-Mediated Severe Hypercalcemia in a Patient With Renal Mass.

Hypercalcemia of malignancy (HCM) is the most common cause of hypercalcemia in hospitalized patients. The pathogenesis of HCM is often multifactorial. One of the rare causes of HCM is extra-renal production of 1,25-dihydroxyvitamin D (or calcitriol), which is often seen in patients with lymphoproliferative malignancies.

Bile acid diarrhea in patients with chronic diarrhea. Current appraisal and recommendations for clinical practice.

Bile Acid Diarrhea (BAD) is a common cause of chronic diarrhea, often accompanied by urgency, occasional fecal incontinence, abdominal pain, and fatigue. A nationwide survey has shown limited awareness of BAD within the Italian medical community, prompting a panel of experts to develop a Position Paper that outlines the most practical and cost-saving diagnostic investigations and treatments for this frequently overlooked condition. The document provides an overview of the epidemiology, pathophysiology, clinical manifestations, and classification of the different types of Bile Acid Diarrhea (BAD).

Aerodynamic performance enhancement of centrifugal compressor using numerical techniques.

Background: Centrifugal compressors are dynamic machines utilizing a rotating impeller, efficiently accelerate incoming gases, transforming kinetic energy into pressure energy for compression. They serve a wide range of industries, including air conditioning, refrigeration, gas turbines, industrial processes, and applications such as air compression, gas transportation, and petrochemicals, demonstrating their versatility. Designing a centrifugal compressor poses challenges related to achieving high aerodynamic efficiency, surge and choke control, material selection, rotor dynamics, cavitation, erosion, and addressing environmental considerations while balancing costs.

Increased BMI is associated with an altered decision-making process during healthy food choices in males and females.

Unhealthy diets (rich in calories, sugar, fat, and sodium) are a major cause of obesity. Why individuals struggle to make healthy food choices remains unclear. This study examined how body mass index, biological sex, and eating context influence food attribute perception, the food choice process, and the percentage of healthy food choices.

Novel combination therapy targeting oncogenic signaling kinase P21 activated Kinase-1 and chemotherapeutic drugs against triple negative breast cancer.

Most of the triple negative phenotype or basal-like molecular subtypes of breast cancers are associated with aggressive clinical behaviour and show poor disease prognosis. Current treatment options are constrained, emphasizing the need for novel combinatorial therapies for this particular tumor subtype. Our group has demonstrated that functionally active p21 activated kinase 1 (PAK1) exhibits significantly higher expression levels in clinical triple negative breast cancer (TNBC) samples compared to other subtypes, as well as adjacent normal tissues.

Staple principles for the definition of front-of-pack nutritional labels.

Front-of-pack nutrition labels (FOPNLs) have been developed since 1989 to curb the increasing prevalence of obesity and non-communicable diseases (NCDs) and to promote healthy consumption choices. While several countries have introduced their own labeling schemes on a voluntary basis, the European Commission aims to harmonize a FOPNL system that will be mandatory for all member states. This paper summarizes a contribution to the current debate on FOPNLs from Italian and Spanish researchers working in the fields of human nutrition, nutritional epidemiology and public health education and communication policy before the final decision on FOPNLs to become mandatory in Europe is taken.

A protocol to study the effect of targeted parental education intervention to identify early childhood development disorder - multisite interventional study.

Background: In India, approximately 3.5 million children are affected by Developmental Delay (DD), often stemming from preterm births. These delays contribute to neurological and motor development delays, placing a significant financial burden on families.

Exploring the clinicopathological parameters of HER2 low breast cancers: insights from a retrospective cohort study.

Purpose: Breast cancer subtypes are delineated by human epidermal growth factor receptor 2 (HER2) expression, pivotal in treatment selection. HER2-positive tumors typically respond to targeted therapies, whereas HER2-negative tumors lack HER2 overexpression. However, a subset exhibits low HER2 expression without amplification, termed HER2 low breast cancer.

Evaluating the Impact of Multimodal Prehabilitation with High Protein Oral Nutritional Supplementation (HP ONS) with Beta-Hydroxy Beta-Methylbutyrate (HMB) on Sarcopenic Surgical Patients-Interim Analysis of the HEROS Study.

Background: Multimodal prehabilitation programs, which may incorporate nutritional supplementation and exercise, have been developed to combat sarcopenia in surgical patients to enhance post-operative outcomes. However, the optimal regime remains unknown. The use of beta-hydroxy beta-methylbutyrate (HMB) has beneficial effects on muscle mass and strength.

Targeting Pseudomonas aeruginosa PAO1 pathogenicity: The role of Glycyrrhiza glabra in inhibiting virulence factors and biofilms.

Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen posing serious risks to immunocompromised individuals due to its virulence factors and biofilm formation. This study evaluated the efficacy of methanol extract of Glycyrrhiza glabra (G.

A case of assisted reproductive technology-induced maternal alloimmunization: an emerging sensitizing factor to consider?

Red blood cell (RBC) alloimmunization can occur because of exposure to various sensitizing factors and poses a constant threat in transfusion. Assisted reproductive technology (ART) involves manipulation of sperm, ova, or embryos with the goal of producing a pregnancy. We present an interesting case of ART-induced maternal alloimmunization (AIMA) due to anti-c in a woman carrying a twin pregnancy.

Understanding Comprehensive Sexuality Education: A Worldwide Narrative Review.

Comprehensive sexuality education (CSE) is curriculum-based teaching and learning of various dimensions of sexuality. By equipping young people with accurate information on sexual and reproductive health, CSE promotes healthier populations and fosters a more informed workforce, contributing positively to national economies. Although known to have many benefits, CSE is not universally accepted or implemented.

Causes and risk factors for stillbirth in India: A systematic review protocol.

Objectives: Stillbirths, the tragic loss of a baby before or during delivery, presents a profound global health concern. Investigating the diverse causes and risk factors is essential to develop targeted interventions, enhance perinatal care, and reduce the incidence of this devastating outcome. The aim of this study was to identify the causes and possible risk factors of stillbirths in India.

A comprehensive review on early detection of drusen patterns in age-related macular degeneration using deep learning models.

Age-related Macular Degeneration (AMD) is a leading cause of visual impairment and blindness that affects the eye from the age of fifty-five and older. It impacts on the retina, the light-sensitive layer of the eye. In early AMD, yellowish deposits called drusen, form under the retina, which could result in distortion and gradual blurring of vision.

Successful Treatment Outcome of a Pediatric Malignant Germ Cell Tumor With an Extensive Cavo-atrial Tumor Thrombus Presenting as an Oncological Emergency.

Background: Pediatric germ cell tumor (GCT) with extensive cavo-atrial tumor thrombus presenting as an oncologic emergency is extremely rare.

Observation: A 13-month-old female child with sacrococcygeal GCT having inferior vena cava (IVC) and right atrial thrombus presenting with anasarca and respiratory distress is reported. Because of worsening symptoms post initiation of chemotherapy, tumor thrombus debulking from the right atrium and distal end of IVC was performed on day 9 on an emergency basis.

Carbon Monoxide in Healthcare Monitoring Balancing Potential and Challenges in Public Health Perspective: A Narrative Review.

Carbon monoxide (CO) has medicinal potential and harmful qualities. However, excessive exposure to CO can lead to severe organ failure. CO is exogenously and endogenously generated within the human body.

Revisit to Endolymphatic Duct Identification Using Middle Cranial Fossa Dural Plate: A Novel Technique.

Objectives: Surgical treatments for Ménière's disease differ in efficacy. Endolymphatic duct blockage (EDB) is favored for its minimal risk and ability to preserve hearing. One of the main challenges in the technique is the difficulty in accurately identifying the endolymphatic duct (ED).

Beverage Combination of Pomegranate Juice and Quinoa Extract Ameliorates Lipid Profile in Rat Study.

Effect of fruit and cereal grain-based beverage studies on the lipid profile are limited. Pomegranate fruit and quinoa grains are known for their abundance of polyphenols with several health beneficial effects. The present study was carried out to investigate the effects of oral administration of beverage containing pomegranate juice and quinoa seed extract in obese rats.

Sensorless vector-controlled induction motor drives: Boosting performance with Adaptive Neuro-Fuzzy Inference System integrated augmented Model Reference Adaptive System.

The Model Reference Adaptive System (MRAS) is effective for speed control in sensorless Induction Motor (IM) drives, particularly at zero and very low speeds. This study enhances MRAS's resilience and dynamic performance by integrating an Adaptive Neuro-Fuzzy Inference System (ANFIS) controller into sensorless vector-controlled IM drives. The research addresses challenges related to parameter uncertainties, load variations, and external disturbances through the combination of MRAS and ANFIS.