Atypical antipsychotic drug olanzapine inhibits 5-HT receptor-mediated currents by allosteric and non-competitive mechanisms.

Olanzapine, an atypical antipsychotic, is widely used in the treatment of schizophrenia and bipolar disorder due to its modulation of dopamine and serotonin receptor systems. While its primary action involves antagonism of dopamine D2 and serotonin 5-HT (5-hydroxytryptamine)A receptors, recent evidence suggests that olanzapine also inhibits 5-HT receptors, which are ligand-gated ion channels involved in synaptic transmission in central and peripheral nervous systems. The present study aimed to investigate the action of olanzapine on 5-HT receptor-mediated currents using whole-cell voltage-clamp recordings in NCB-20 neuroblastoma cells.

Quetiapine competitively inhibits 5-HT receptor-mediated currents in NCB20 neuroblastoma cells.

The 5-hydroxytryptamine type (5-HT) receptor, a ligand-gated ion channel, plays a critical role in synaptic transmission. It has been implicated in various neuropsychiatric disorders. This study aimed to elucidate the mechanism by which quetiapine, an atypical antipsychotic, could inhibit 5-HT receptor-mediated currents in NCB20 neuroblastoma cells.

Haloperidol, a typical antipsychotic, inhibits 5-HT receptormediated currents in NCB-20 cells: a whole-cell patch-clamp study.

Haloperidol is a typical antipsychotic drug effective in alleviating positive symptoms of schizophrenia by blocking dopamine receptor 2 (DR2). However, it is also known to produce neuropsychiatric effects by acting on various targets other than DR. In this study, we investigated effect of haloperidol on function of 5-hydroxytryptamine (5-HT) receptor, a ligand-gated ion channel belonging to the serotonin receptor family using the whole-cell voltage clamp technique and NCB20 neuroblastoma cells.

Methyl Gallate Suppresses Canine Mammary Gland Tumors by Inducing Apoptosis and Anti-angiogenesis.

Background/aim: Methyl gallate (MG), a plant phenolic compound, has known anticancer properties. However, its effects on canine mammary gland tumors (CMTs) are unclear. This study evaluated the impact of MG on cell viability, migration, and apoptosis in two CMT cell lines.

Enhancing Microalgae Content in Biocomposites through a Mechanical Grinding Method.

Microalgae-based biocomposites are gaining traction as ecofriendly and cost-effective alternatives to conventional petroleum-based plastics. However, achieving a homogeneous dispersion of microalgae within a biocomposite matrix remains a challenge. In this study, we investigated the effect of the size of dried microalgae ( sp.

Improving Printability of Digital-Light-Processing 3D Bioprinting via Photoabsorber Pigment Adjustment.

Digital-light-processing (DLP) three-dimensional (3D) bioprinting, which has a rapid printing speed and high precision, requires optimized biomaterial ink to ensure photocrosslinking for successful printing. However, optimization studies on DLP bioprinting have yet to sufficiently explore the measurement of light exposure energy and biomaterial ink absorbance controls to improve the printability. In this study, we synchronized the light wavelength of the projection base printer with the absorption wavelength of the biomaterial ink.

Unsupervised Monocular Depth Estimation for Colonoscope System Using Feedback Network.

A colonoscopy is a medical examination used to check disease or abnormalities in the large intestine. If necessary, polyps or adenomas would be removed through the scope during a colonoscopy. Colorectal cancer can be prevented through this.

Over 1.4 V for Amorphous Tin-Oxide-Based Dopant-Free CsPbIBr Perovskite Solar Cells.

CsPbIBr perovskite solar cells have attracted much attention because of the rapid development in their efficiency and their great potential as a top cell of tandem solar cells. However, the outputs observed so far in most cases are far from that desired for a top cell. Up to now, with various kinds of treatments, the reported champion is only 1.

Proton Irradiation Tolerance of High-Efficiency Perovskite Absorbers for Space Applications.

Lead halide perovskite single layers with three grain sizes are subjected to proton-beam irradiation in order to assess the durability and radiation tolerance of perovskite solar cells (PSCs) against space radiation. Proton-beam irradiation is chosen because proton beams significantly affect solar cell performance in the space environment. We evaluate the effects of proton beams by focusing on the grain structure, crystal structure, and carrier lifetime of a perovskite single layer by using scanning electron microscopy, X-ray diffraction, photoluminescence (PL) spectra, and time-resolved PL (TRPL).

Semi-transparent Perovskite Solar Cells Developed by Considering Human Luminosity Function.

Semi-transparent solar cells draw a great deal of attention because their applications include, for instance, photovoltaic windows. General approach to semi-transparent cells is using thin active layers or island-type structures. Here we take human luminosity function into account, and develop solar cells that harvest photons in the wavelength regions in which human eyes are less sensitive to light.

Plasmonic Photovoltaic Cells with Dual-Functional Gold, Silver, and Copper Half-Shell Arrays.

Solid-state photovoltaic cells based on plasmon-induced charge separation (PICS) have attracted growing attention during the past decade. However, the power conversion efficiency (PCE) of the previously reported devices, which are generally loaded with dispersed metal nanoparticles as light absorbers, has not been sufficiently high. Here we report simpler plasmonic photovoltaic cells with interconnected Au, Ag, and Cu half-shell arrays deposited on SiO@TiO colloidal crystals, which serve both as a plasmonic light absorber and as a current collector.

Synthesis and Characteristics of Fullerene Derivatives with Hexyl Perylene Moieties as N-Type Materials in Organic Solar Cells.

Recently, fullerene derivatives have received significant attention due to their potential impacts on the development of high performance organic photovoltaic (OPV) cells. One of the most successful fullerene derivatives thus far is [6, 6]-phenyl-C61-butyric acid methyl ester (PCBM), which is being used as an electron acceptor material. However, PCBM has some disadvantages concerning its application in OPV cells, such as a weak absorption rate in the visible region and a relatively low LUMO level.

Studies on the Properties of Organic Photovoltaic Cells Using TiOx and DMDCNQI as Double Buffer Layers.

Various types of n-type buffer layers have been used in organic electronic devices. These buffer layers turned out to expedite carrier injection and reduce series resistance, leading to good performance of organic electronic devices. In our current work, we have fabricated organic photovoltaic (OPV) cells consisting of ITO/PEDOT:PSS/P3HT:PCBM/TiOx/DMDCNQI/AI which were fabricated in the presence of air.