Reliability and Validity of the Korean Version of the Spinal Cord Independence Measure III.

Objective: Given the lack of a Korean version of the Spinal Cord Independence Measure III (KSCIM-III) that accurately reflects the contextual and cultural aspect of the assessment tool, the aims of the study were to develop a new Korean version of the Spinal Cord Independence Measure III and to investigate its reliability and validity.

Design: Forty (N = 40) consecutive patients with spinal cord injury were included in this prospective study. Backward and forward translation of the Spinal Cord Independence Measure III was performed by fluent speakers in both languages.

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons.

Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied by a loss of Golgi outposts (GOPs) and a decreased supply of plasma membrane (PM) in Drosophila class IV dendritic arborization (da) (C4 da) neurons. mRNA sequencing revealed that genes downregulated by polyQ proteins included many secretory pathway-related genes, including COPII genes regulating GOP synthesis.

Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome.

Hutchinson-Gilford progeria syndrome (HGPS) constitutes a genetic disease wherein an aging phenotype manifests in childhood. Recent studies indicate that reactive oxygen species (ROS) play important roles in HGPS phenotype progression. Thus, pharmacological reduction in ROS levels has been proposed as a potentially effective treatment for patient with this disorder.