Publications by authors named "Gyu Nam Jang"
Article Synopsis
- Bone tissue regeneration relies on complex biological processes, and the development of biomaterials that can effectively regulate these processes could enhance healing.
- A new multi-functional nanoparticle combined with a hydrogel has been developed, showing promise for osteoinduction, inflammation control, and the regulation of osteoclast maturation to improve bone regeneration.
- Experimental results demonstrate that the tannic acid-mineral nanoparticle hydrogel shows excellent biocompatibility and enhances osteogenic gene expression in human stem cells compared to traditional gel without the nanoparticles.
Bone healing involves complex processes including inflammation, induction, and remodeling. In this context, anti-inflammatory and osteoconductive multi-functional nanoparticles have attracted considerable attention for application in improved bone tissue regeneration. In particular, nanoparticles that promote suppression of inflammatory response after injury and direction of desirable tissue regeneration events are of immense interest to researchers.
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- Researchers created advanced 3D-printed scaffolds for bone regeneration featuring bioactive surfaces coated with minerals and platelet-derived growth factor (PDGF) to address challenges in growing complex bone structures with blood vessels.
- The scaffolds enhanced mineral coating with a specific solution, leading to improved strength and effectively promoted stem cell differentiation and production of pro-angiogenic factors.
- In animal tests, the new scaffolds significantly regenerated bone and blood vessel structures in about 80% of the treated areas after 8 weeks, showcasing their potential for therapeutic use in bone repair.
Biofabrication of organ-like engineered 3D tissue through the assembly of magnetized 3D multi-cellular spheroids has been recently investigated in tissue engineering. However, the cytotoxicity of magnetic nanoparticles (MNPs) and contraction-induced structural deformation of the constructs have been major limitations. In this study, we developed a method to fabricate composite stem cell spheroids using MNP-coated fibers, alleviating MNP-mediated toxicity and controlling structural assembly under external magnetic stimuli.
View Article and Find Full Text PDFStem cell spheroids have been widely investigated to accelerate bone tissue regeneration. However, the directed differentiation of stem cells into osteoblastic lineage and the prevention of cells from damage by reactive oxygen species (ROS) remain challenge. Here, we developed osteoinductive and ROS scavenging extracellular matrix-mimicking synthetic fibers based on epigallocatechin gallate (EGCG) coating.
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