The endogenous release of pancreatic polypeptide by acid and meal in dogs. Effect of somatostatin.

The response of pancreatic polypeptide (PP) to testmeal (5 ml/kg) and intraduodenal acid (4 mEq HCl/5min) and its reaction to somatostatin (3.5 microgram/kg/h following bolus injection of 3.5 microgram/kg) was studied in dogs with chronic duodenal and gastric fistulae.

Effect of somatostatin on exocrine pancreatic secretion stimulated by pancreozymin-secretin or by a test meal in the dog.

In 4 dogs with chronic duodenal and gastric fistulae, exocrine pancreatic function was assessed by cannulating the pancreatic duct and collecting the duodenal contents. Both methods were applied in each animal. Pancreatic secretion was stimulated by infusion of 2 CHR units of pancreozymin and secretin or by administration of a liquid test meal, injected into the stomach through the gastric fistula.

[Falciparum malaria in Switzerland: a problem of intensive care?].

In the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chemoprophylaxis and in all of them several days had elapsed between onset of symptoms and diagnosis.

Influence of glucagon on exocrine pancreatic function as determined by the Lundh test in dogs.

Exocrine pancreatic function was investigated by means of the Lundh test model in dogs with chronic duodenal and gastric fistulas. The test was standardized and the effect of glucagon on exocrine pancreatic secretion was evaluated. The mean tryptic activity detected in 18 tests in 6 dogs was 32.

[Prospective study of the 1st 197 endoscopic retrograde cholangio-pancreatographies (ERCP) in Basel (1973-1975)].

Cannulation of the papilla has been successful in 144 out of 197 ERCPs. The rate of success increases with the experience of the endoscopist. The intended filling of the pancreatic duct was successful in 87%, of the bile ducts in 64% and of both duct systems in 28%.

Polymorphonuclear neutrophilic leukocytes in protein deficiency.

The number of white blood cells and of polymorphonuclear leukocytes remained unchanged in vervet monkeys (Cercopithecus aethiops) receiving a "O" protein diet. The motility of the polymorphonuclear leukocytes and their phagocytic and killing indices with and without leukokinin stimulation decreased in protein-depleted animals. Acid cathepsin decreased, DNA relatively increased, and peroxidase, alkaline phosphatase, acid phenylphosphatase, and lysozyme reached higher levels in the polymorphonuclear leukocytes of animals on a "O" protein diet.

Formazan cells in protein and protein-calorie malnutrition.

Formazan cells were less numerous in the peripheral blood of vervet monkeys (Cercopithecus aethiops) receiving a "O" protein-low calorie diet than in animals fed a full or a protein but not calorie deficient diet.

Action of some pancreatic enzymes on Vibrio cholerae.

The action of pancreatic amylase, trypsin, lipase, and whole pancreatin was tested on five strains of Bibrio cholerae. Amylase did not act on any strain in concentrations to 10,000 IU/ml whereas trypsin increased vacuolization and lipase enhanced retraction of the protoplasm particularly in 2 of the 5 tested vibrio strains. Pancreatin caused damage hoth of the cell wall and the cytoplasm.

[Effect of somatostatin on canine exocrine pancreas secretion stimulated by pancreozymin, secretin or test meal].

In 4 dogs with pancreatic and gastric fistulae the effect of somatostatin (SST) on the pancreas was investigated during stimulation by pancreozymin-secretin or by a test meal. The pancreozymin-secretin-induced enzyme output and bile flow, as well as the enzyme concentration and duodenal volume during test meal stimulation were significantly reduced by SST. SST caused a less marked decrease in bicarbonate concentration, while volume and bicarbonate output did not change.

[Effect of orally administered pancreatic extract on Vibrio cholerae infection during protein deficiency].

Two groups of 5 and 6 Vervet monkeys respectively were fed a protein-free diet. Both groups of protein depleted Vervets developed a minor decrease of serum and intestinal immunoglobulins, as well as marked impairment of exocrine pancreatic function. Thereafter the groups were challenged with Vibrio cholerae, while one group received purified pancreatic extract by oral administration.

[New therapeutic possibilities in the diagnosis of congenital cystic bile duct dilatations (author's transl)].

The case of a 30-year-old woman with intra- and extrahepatic biliary dilatations (Caroli's disease) is reported. The features of the disease and its differential diagnosis are discussed. Special reference is given to the diagnostic approach by endoscopic retrograde cholangiography and to treatment with Chenodeoxy-cholicacid.

[Results of coloscopy of polypectomy in the years 1974-1975 at the Basel county hospital].

The diagnostic value of coloscopy was assessed by analysis of the endoscopic findings in 310 patients investigated between January 1974 and December 1975. Altogether, 342 coloscopies were performed with a complication rate of 1.5% (3 perforations, 2 hemorrhages).

[Elementary diet as an alternative to parenteral feeding in severe gastrointestinal diseases].

21 patients with gastroenterological disease and indication for the use of intravenous nutrition received an elemental diet (ED) for 5-44 days. In 6 out of 8 patients with exacerbation of Crohn's disease remissions were achieved, apart from 3 persistent fistulas. In 5 out of 9 cases with various primary diseases and postoperative intestinal fistulas, spontaneous healing was observed.

Therapy of alveococcosis in man.

Diagnostic, therapeutic and prognostic aspects are interpreted on the basis of two cases of Echinococcus alveolaris. Both patients had undergone partial hepatectomy and were subsequently treated chemotherapeutically. In one case dehydroemetine and mebendazole (Vermox, Janssen), and in the other case metrifonate (Bilarcil, Bayer A.

Acute intermittent porphyria with relapsing acute pancreatitis and unconjugated hyperbilirubinemia without overt hemolysis.

A 36-year-old woman was admitted to hospital with a first attack of acute intermittent porphyria. At the same time increased serum levels of amylase and lipase as well as an increased amylase clearance to creatinine clearance ratio were observed, permitting the diagnosis of acute pancreatitis. The etiology of the latter could not be determined.

Exocrine pancreatic function, intestinal resorption and reaction to Vibrio cholerae infection in protein deficiency.

Six Patas monkeys were fed a protein-free diet while 16 animals of the same species receoved a standard monkey diet. The protein-depleted monkeys showed reduced absorption of folic acid but not Dxylose, and 5 out of 6 exhibited depressed exocrine pancreatic function. When challenged with Vibrio cholerae, animals with reduced folic acid absorption and pancreatic enzyme production excreted the micro-organisms for a longer time.

[Frequency of amebiasis and other intestinal protozoal diseases. An epidemiological study with the aid of MIF technic].

Advantages and disadvantages of various laboratory techniques used for the diagnosis of intestinal protozoa are discussed. The importance of a correct parasitological diagnosis is emphasized. The MIF procedure has been investigated with regard to its reliability and found to be very effective due to its high diagnostic yield and reproducibility in repeated examinations.

Oral administration of a chymotrypsin-labile peptide--a new test of exocrine pancreatic function in man (PFT).

One gram N-benzoyl-L-tyrosyl PABA was orally administered to 24 controls, 15 patients with chronic exocrine pancreatic disease, 13 patients after an attack of acute pancreatitis, two patients with gluten-sensitive enteropathy, and 10 patients with biliary tract disease, peptic ulcer, or other pathology of the gastrointestinal tract. In the presence of chymotrypsin, PABA is split from the peptide and excreted in the urine. The amount of PABA excreted serves as a parameter of exocrine pancreatic function.

Malnutrition and susceptibility to infection with Vibrio cholerae in vervet monkeys (Cercopithecus aethiops). 2. Response of vervet monkeys on protein, B-vitamin complex and calorie-deficient diets to infection.

Five groups of vervet monkeys (Cercopithecus aethiops) were fed regular monkey chow, low protein (LP), low B-vitamin complex (LBV), LP-LBV, or low protein- low calorie (LP-LC) diets, respectively. After eight weeks the animals were infected with cholera vibrios. IgG, IgA and IgM increased in the sera of all animals after the challenge but the avidity of the immunoglobulins was lower in vervets on LP diets.

Malnutrition and susceptibility to infection with Vibrio cholerae in vervet monkeys (Cercopithecus aethiops). 1. Induction of protein, B-vitamin complex and calorie malnutrition.

Five groups of eight vervet monkeys (Cercopithecus aethiops) were fed regular monkey chow, low protein (LP), low B-vitamin complex (LBV), low protein - low B-vitamin complex (LB-LBV), or protein - low calorie (LP-LC) diet, respectively, for eight weeks. Hematocrit values, hemoglobin, BUN, total protein, albumin, riboflavin and body weight decreased, the ratio of dispensable/indispensable amino acids increased in all animals receiving a deficient diet. Total globulin, IgG and IgM remained unchanged in vervets on LBV diet; panthotenic acid and cyanocobalamin in animals receiving LBV, LP or LP-LC chow; and pyridoxal on the LP or LP-LC diet.

[First experiences with a new oral human pancreas function test with special emphasis on gastric voiding].

1 g of N--benzoyl-L-tyrosyl-PABA was administered orally to 50 test persons, i.e. controls and patients with known pancreatic disease.