Publications by authors named "Gyeong-Seo Park"
Article Synopsis
- Caseous lymphadenitis (CLA) is a bacterial disease affecting ruminants that has seen a rise in cases in South Korea since 2014, prompting the development of a new vaccine.
- Researchers created the first inactivated CLA vaccine in South Korea and tested its effectiveness through trials on mice, guinea pigs, and Korean Native Black Goats (KNBGs), finding no clinical symptoms in vaccinated KNBGs and significant levels of CLA-specific IgG.
- The vaccine is designed to prevent infection from a variety of CLA strains, with the potential to protect livestock and support the growth of the domestic KNBG industry in South Korea.
Background: This field efficacy study was designed to determine the efficacy of a new bivalent vaccine containing porcine circovirus type 2d (PCV2d) and Mycoplasma hyopneumoniae at three independent pig farms.
Methods: Three pig farms were selected based on their history of subclinical PCV2 infection and enzootic pneumonia. Each farm housed a total of 40, 18-day-old pigs that were randomly allocated to 1 of 2 treatment groups.
Background: This field evaluation was designed to evaluate the efficacy of a new porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) modified live virus vaccine at three independent pig farms.
Methods: Three farms were selected for this study based on their respiratory disease status caused by PRRSV-2 infection in post-weaning and growing pigs. Each farm housed a total of 40, 18-day-old pigs that were randomly allocated to one of two treatment groups.
Porcine reproductive and respiratory syndrome (PRRS) is a disease that has inflicted economic losses in the swine industry. The causative agent, porcine reproductive and respiratory syndrome virus (PRRSV), is known to have a high genetic diversity which leads to heterogeneous pathogenicity. To date, the impact of PRRS outbreaks on swine production and the economy of the swine industry in South Korea has been rarely reported.
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- PRRSV (Porcine reproductive and respiratory syndrome virus) significantly impacts the global swine industry due to its high genetic and pathogenic variability, divided into European (PRRSV1) and North American (PRRSV2) strains.
- This study employed a new method, SISPA-NGS, for whole-genome sequencing of Korean PRRSV strains, enabling detailed genetic characterization and phylogenetic analysis.
- Results identified distinct lineages among Korean PRRSV strains, revealed conserved genetic patterns, and indicated natural recombination events, enhancing understanding of the virus's evolution and variants in the region.
Article Synopsis
- The study investigates the prevalence of classical porcine parvovirus (PPV1) and newer strains (PPV2-PPV7) in pig populations in Korea, analyzing various biological samples collected between 2018 and 2020.
- Findings indicate that these viruses are widespread, with the highest detection rates in lung samples, particularly in fattening pigs, suggesting a chronic infection cycle.
- The presence of PPVs was notably higher in samples co-infected with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory virus (PRRSV), highlighting the potential interactions between these pathogens and the need for further research into their combined effects.
Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important pathogen in the Korean swine industry. Despite efforts including improved biosecurity and vaccination protocols, the virus continues to circulate and evolve. Based on phylogenetic analysis of open reading frame 5 (ORF5), Korean PRRSVs are known to form not only globally circulating lineages but also country-specific lineages (Lin Kor A, B, and C).
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