Publications by authors named "Gyehyun Lee"
Article Synopsis
- - This study focused on developing a new imaging-based method called single-cell spatial transcriptomics (iSCST) to analyze archived, formalin-fixed, paraffin-embedded (FFPE) tissue samples from inflammatory bowel disease (IBD) patients, which helps to preserve the spatial context of various cell types within the tissue.
- - Researchers benchmarked three iSCST platforms by analyzing 57 FFPE mucosal biopsies from IBD patients and healthy controls, allowing for detailed cell analysis and gene expression profiling through a consistent data processing pipeline.
- - A custom gene panel showed the best performance for detecting and quantifying different cell subsets, revealing significant findings related to inflammation and treatment responses in ulcerative colitis, which could enhance
Thermodynamic modulation of gephyrin condensation by inhibitory synapse components.
Proc Natl Acad Sci U S A
March 2024
Phase separation drives compartmentalization of intracellular contents into various biomolecular condensates. Individual condensate components are thought to differentially contribute to the organization and function of condensates. However, how intermolecular interactions among constituent biomolecules modulate the phase behaviors of multicomponent condensates remains unclear.
View Article and Find Full Text PDFUlcerative colitis (UC) is driven by immune and stromal subsets, culminating in epithelial injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is known to inhibit lymphocyte trafficking to the intestine, but its broader effects on other cell subsets are less defined.
View Article and Find Full Text PDFUlcerative colitis (UC) is driven by immune and stromal subsets, culminating in epithelial injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is known to inhibit lymphocyte trafficking to the intestine, but its broader effects on other cell subsets are less defined.
View Article and Find Full Text PDF