Evaluating the capacity of paired comparison methods to aggregate rankings of separate groups.

Ranking and rating methods have outstanding significance in sports, mainly due to their capacity to predict results. In this paper we turn to their capacity to aggregate separate groups' rankings based on a small piece of information. We investigate under which conditions two or more separate groups can be trustworthily interwoven applying Thurstone motivated methods and an AHP based method.

[Absorption and distribution of benzyloxyamine-containing aerosols (author's transl)].

The study of the blood levels and tissue concentrations in mice to which 14C-benzyloxyamine hydrochloride was applied in the form of a spray and of a suspensoid aerosol evidenced the good abosrption of this pharmacon. Maximum blood levels were observed 0.5 hour after administration of the spray.

The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats.

The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated.

Evaluation of correlation between selected rheological parameters of ointments and their in vitro release data.

A comparative study was done by the authors between the active substance release characteristic of lipophilic and hydrophilic oitment bases and their rheological parameters. There was stated a significant difference due to the matrix concentration the last being an essential factor in determining the effective surface area. The water solubility of matrix constituents is plaxing an important role in formation of the effective surface area.

A contribution to the kinetics of dissolution of some modern drugs.

A report is presented on the investigation of some drugs being used in modern therapy from the point of view of dissolution kinetics in aqueous and in aqueous micellar solutions. It has been established that the dissolution (saturation) process, in accordance with previous assumptions, is kinetically of the first order both in aqueous and in aqueous micellar solutions. The rate constants describing these processes are nearly identical for the same drug, hence the saturation rates are nearly identical.