Levels of F(1+2) prothrombin fragments and thrombin - antithrombin III (TAT) complexes in patients with dermatitis herpetiformis.

Background: Dermatitis herpetiformis (DH) is a rare bullous disease of autoimmune etiology. It is an intestinocutaneous syndrome, in which vesicopapular cutaneous lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin fragment (granular IgA deposits present at the tops of dermal papillae and IgA - EmA present in the serum).

Selected parameters of fibrinolysis system in patients with dermatitis herpetiformis.

Background: Dermatitis herpetiformis (DH) is a very rare bullous dermatitis of autoimmune origin. It is a syndrome involving dermal and intestinal pathology, in which vesicopapular skin lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin bioptate (presence of granular IgA deposits in the upper portions of dermal papillae).

[In vitro assessment of the sensitivity of Candida albicans strains isolated from the vagina on basis antimycotics].

Objective: The purpose of the study was to analyses the sensitivity of 73 randomly selected Candida albicans strains isolated from the vagina of pregnant and delivering women against seven basic antimycotics.

Materials And Methods: The microtest FUNGITEST (Sanofi Diagnostics Pasteur) was applied in assessing the sensitivity of 5-fluorocytosin, amphotericin B, ketoconazol, fluconazol, itraconazol and miconazol and the disk-diffusion method with the use of a Casitone base for nystatin.

Results And Conclusions: Variations in the sensitivity against drugs have been noted between individual strains of Candida albicans species.

[Yeast species identification in vulvovaginal candidiasis: susceptibility to nystatin].

Objective: The rates of Candida species and susceptibility to nystatin were evaluated.

Materials And Methods: In the period from January 1, 1998 to December 31, 1998 mycological tests have been carried out for identification of yeast species in the group of pregnant and delivering women hospitalized in the Obstetrics-Gynecological Departments of the Municipal Hospital in Bydgoszcz. We used two commercial media: Albicans ID and CHROMagar Candida.

Short-term itraconazole versus terbinafine in the treatment of tinea pedis or manus.

A total of 304 patients with a clinical diagnosis of palmar-type tinea pedis or manus and a positive mycologic examination were recruited into this double-blind, randomized, multicenter, phase III study. Patients were randomized to receive either oral itraconazole 200 mg twice daily (in the morning and evening) for 7 days, followed by placebo for 7 days (n = 153), or placebo in the morning and oral terbinafine 250 mg in the evening for 14 days (n = 151). At the first visit and 1, 2, and 6 weeks after the start of the study, signs and symptoms were assessed clinically, and scales were taken for mycologic assessments (microscopy and culture).

The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers.

The unpleasant smell of infected fungating tumors and benign cutaneous ulcers is a distressing clinical problem, known to be associated with anaerobic infection. Topical metronidazole 0.8% gel has been shown to decrease smell from fungating malodorous tumors.

[A case of Lyell's syndrome caused by carbamazepine].

A case is described of Lyell syndrome in a female patient with schizoaffective psychosis which developed several days after addition of carbamazepine to the psychotropic treatment used. After withdrawal of the drug and three weeks of treatment with prednisone in dose 60 mg daily, antibiotic therapy and intensive dermatological-nursing care, full remission of skin lesions and oral mucosa lesions was obtained.

[Phenomenon of increased resistance of yeast-like fungi to nystatin].

The results are presented of in vitro investigations of the sensitivity of 225 strains of yeast-like fungi to nystatin. The strains were isolated from cutaneous and mucosal lesions. In the study nystatin concentration 10 micrograms/ml of the substrate was used and a two-grade scale of evaluation was applied: sensitive or resistant to the drug.

[Antifungal activity of itraconazole and ketoconazole investigated in vitro, determined with minimal inhibitory concentrations and mycelial cell transformation in Candida albicans].

Results of studies "in vitro" of the susceptibility of 82 strains of Candida albicans for itraconazole and ketoconazole have been report. The strains were isolated from lesions of the mucous membranes and skin. The susceptibility of Candida albicans was tested to Minimal Inhibitory Concentration (MIC) and Total Inhibition Germination Tubes (TI100).

[Comparison of the susceptibility of Candida strains to ketoconazole and itraconazole in in vitro experiments].

The activity of ketoconazole and itraconazole against 102 strains of Candida sp. was compared in the investigation "in vitro". The investigational material was taken from patients with different types of mycosis.

[Griseofulvin in the treatment of herpes zoster].

The authors applied griseofulvin in 46 patients (28 women and 18 men) aged from 21 to 82 years with various forms of zoster. The locations of lesions was different: concerned very often the face and the thorax, rarely the extremities and sometimes the lesions were generalized. The treatment was started in beginning stadium of disease.

[Effect of itraconazole on the process of mycelial transformation of Candida albicans cells in human serum].

Results of in vitro studies on the influence of itraconazole on mycelial transformation of 88 Candida albicans strains are presented. The drug influenced a number of cells capable to produce filaments. The number of those cells diminished gradually together with the increase of the drug concentration.

[In vitro investigations of Candida strains for itraconazole].

Results of studies in vitro of the susceptibility of 102 strains of Candida type (88--Candida albicans, 7--Candida intermedia, 3--Candida parapsilosis, 1--Candida stellatoidea, 3--Torulopsis candida), to itraconazole have been reported. The strains were isolated from lesions of the skin and mucous membranes. The strains tested showed no resistance to this drug.