Publications by authors named "Gwendoline Morin"
Misfolding of the cellular PrP (PrP) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrP induces complete resistance to prion disease. The aim of this work was to engineer Alpine goats carrying knockout (KO) alleles of PRNP, the PrP-encoding gene, using CRISPR/Cas9-ribonucleoproteins and single-stranded donor oligonucleotides.
View Article and Find Full Text PDFLipid overnutrition in female rabbits, from prepuberty, leads to impaired metabolism (dyslipidemia and increased adiposity) and follicular atresia, and, when continued during gestation, affects offspring phenotype with intrauterine growth retardation (IUGR) and leads to placental and lipid metabolism abnormalities. Growth retardation is already observed in embryo stage, indicating a possible implication of periconceptional exposure. The objective of this study was to discriminate the effects of preconception and gestational exposures on feto-placental development.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how exposure to diesel engine exhaust (DE) during pregnancy affects the long-term health of rabbit offspring, specifically focusing on their cardiovascular and metabolic profiles in adulthood.
- - Female rabbits were exposed to DE or clean air during gestation, and their offspring were monitored for various health metrics, revealing that males experienced more significant negative health consequences compared to females.
- - Findings indicate that male offspring exhibited signs of metabolic syndrome, such as increased blood pressure and altered cholesterol levels, while female offspring showed milder effects, highlighting sex-specific vulnerabilities to air pollution during development.