Abnormalities in gamma-band responses to language stimuli in first-degree relatives of children with autism spectrum disorder: an MEG study.

Background: Synchronous neural oscillatory activity in the gamma range (30-80 Hz) has been shown to be abnormal in individuals with autism spectrum disorders (ASD) and their first-degree relatives in response to simple auditory stimuli. Gamma-band abnormalities in ASD probands have been seen in response to language stimuli, but this has not been investigated in first-degree relatives. This is of particular interest given that language impairments are a core symptom of ASD and may be part of the broad autism phenotype (BAP) seen in relatives.

Not all analogies are created equal: Associative and categorical analogy processing following brain damage.

Current research on analogy processing assumes that different conceptual relations are treated similarly. However, just as words and concepts are related in distinct ways, different kinds of analogies may employ distinct types of relationships. An important distinction in how words are related is the difference between associative (dog-bone) and categorical (dog-cat) relations.

From novel to familiar: tuning the brain for metaphors.

Metaphors are fundamental to creative thought and expression. Newly coined metaphors regularly infiltrate our collective vocabulary and gradually become familiar, but it is unclear how this shift from novel to conventionalized meaning happens in the brain. We investigated the neural career of metaphors in a functional magnetic resonance imaging study using extensively normed new metaphors and simulated the ordinary, gradual experience of metaphor conventionalization by manipulating participants' exposure to these metaphors.

Deconstructing events: the neural bases for space, time, and causality.

Space, time, and causality provide a natural structure for organizing our experience. These abstract categories allow us to think relationally in the most basic sense; understanding simple events requires one to represent the spatial relations among objects, the relative durations of actions or movements, and the links between causes and effects. The present fMRI study investigates the extent to which the brain distinguishes between these fundamental conceptual domains.

Stimulus design is an obstacle course: 560 matched literal and metaphorical sentences for testing neural hypotheses about metaphor.

Despite the ubiquity and importance of metaphor in thought and communication, its neural mediation remains elusive. We suggest that this uncertainty reflects, in part, stimuli that have not been designed with recent conceptual frameworks in mind or that have been hampered by inadvertent differences between metaphoric and literal conditions. In this article, we begin addressing these shortcomings by developing a large, flexible, extensively normed, and theoretically motivated set of metaphoric and literal sentences.

Prescribed spatial prepositions influence how we think about time.

Prepositions combine with nouns flexibly when describing concrete locative relations (e.g. at/on/in the school) but are rigidly prescribed when paired with abstract concepts (e.

Beyond laterality: a critical assessment of research on the neural basis of metaphor.

Metaphors are a fundamental aspect of human cognition. The major neuropsychological hypothesis that metaphoric processing relies primarily on the right hemisphere is not confirmed consistently. We propose ways to advance our understanding of the neuropsychology of metaphor that go beyond simple laterality.

Neural correlates of metaphor processing: the roles of figurativeness, familiarity and difficulty.

There is currently much interest in investigating the neural substrates of metaphor processing. In particular, it has been suggested that the right hemisphere plays a special role in the comprehension of figurative (non-literal) language, and in particular metaphors. However, some studies find no evidence of right hemisphere involvement in metaphor comprehension (e.

Absence of M100 source asymmetry in autism associated with language functioning.

Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with language functioning.