Best practice recommendations for medically assisted reproduction in patients with known cardiovascular disease or at high risk of cardiovascular disease.

Increasing numbers of people are seeking assisted conception. In people with known cardiac disease or risk factors for cardiac disease, assisted conception may carry increased risks during treatment and any subsequent pregnancy. These risks should be assessed, considered and minimized prior to treatment.

Surgery for women with endometrioma prior to fertilisation: proposal for a feasible multicentre randomised clinical trial in the UK.

Study Question: Is it feasible to undertake a randomised controlled trial to establish whether surgical removal of endometrioma or not, improves live birth rates from IVF?

Summary Answer: A randomised controlled trial (RCT) comparing surgery versus no surgery to endometrioma prior to IVF is only feasible in UK if an adaptive rather than traditional study design is used; this would minimise resource wastage and complete the trial in an acceptable time frame.

What Is Known Already: There is wide variation in the management of endometriomas prior to IVF, with decisions about treatment being influenced by personal preferences.

Study Design Size And Duration: This was a mixed-methods study consisting of an online survey of clinicians, a focus group and individual interviews with potential trial participants.