Publications by authors named "Gwen Leatherman"
Article Synopsis
- - The study aimed to explore whether differences in autoantibodies among self-identified black and white systemic sclerosis (SSc) patients contributed to racial variations in disease severity, analyzing 803 black and 2,178 white patients.
- - Results indicated that specific autoantibodies were more prevalent in black patients, who also experienced more severe symptoms, particularly in areas like lung, skin, and renal disease, while white patients had more heart and muscle issues.
- - The findings suggest that although autoantibodies play a role in disease outcomes, they only partially explain the racial disparities observed, implying that other factors must also be considered in understanding these differences.
Objective: OPC-28326 is a selective alpha-adrenergic antagonist with preferential binding to the alpha(2C)-adrenergic receptor (alpha(2C)-AR) subtype. This study observed the effect of OPC-28326 on skin temperature and digital blood flow following an acute cold challenge in patients with Raynaud's phenomenon secondary to scleroderma.
Methods: The study was designed as a single-center, double-blind, placebo-controlled, randomized, 3-period crossover study of OPC-28326 (oral doses of 10 mg or 40 mg) or placebo.