Publications by authors named "Gwangsook Ahn"
Article Synopsis
- CrebH is a key transcription factor primarily found in the liver and small intestine, and its role in gut-liver interactions, particularly in relation to liver disease and IBD, is not well understood.
- In models of IBD and primary sclerosing cholangitis (PSC), CrebH deficiency resulted in accelerated liver injury and enhanced inflammatory responses, indicating its significant influence on these conditions.
- The study identified miR-29a-3p as a crucial factor in promoting inflammation through adhesion molecule expression, showing that exosomes from CrebH-deficient mice can trigger inflammatory signals in the liver of wild-type mice with IBD.
Background: Enteroviruses are known as major pathogen for aseptic meningitis. Although rapid diagnosis for enteroviruses is very essential to exclude bacterial infections in patients with meningitis, classical diagnostic method based on virus isolation is not practicable for timely treatment of patients due to its laborious and time-consuming procedure. Recently molecular methodologies as alternatives are routinely used for rapid and sensitive diagnosis for enteroviruses infections.
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- Enteroviruses were isolated from patients with aseptic meningitis and related diseases in Chungnam, Korea between 2005 and 2006, with isolation rates of 15.2% in 2005 and 9.6% in 2006.
- The study identified 116 enterovirus isolates classified into 13 types, highlighting the prevalence of echoviruses 18, 5, and 25, with echoviruses 5 and 18 being newly identified in Korea since 1993.
- The seasonal outbreaks mostly occurred from June to August, primarily affecting children under 1 year old, with a male to female ratio of about 1.8:1.
Background: Sitosterolemia is an autosomal recessive disorder that maps to the sitosterolemia locus, STSL, on human chromosome 2p21. Two genes, ABCG5 and ABCG8, comprise the STSL and mutations in either cause sitosterolemia. ABCG5 and ABCG8 are thought to have evolved by gene duplication event and are arranged in a head-to-head configuration.
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