Publications by authors named "Gwangheum Yoon"
Injectable, long-acting drug delivery systems provide effective drug concentrations in the blood for up to 6 months. Naltrexone-loaded poly(lactide-co-glycolide) (PLGA) microparticles were prepared using an in-line homogenization method. It allows the transition from a laboratory scale to scale-up production.
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- PLGA-based depot formulations have been clinically used since 1989, but only 19 drugs have FDA approval due to challenges in understanding PLGA polymers and microparticle formation.
- Developments in new analytical methods have improved characterization of non-linear PLGA forms, allowing for better differentiation based on their lactide:glycolide ratios.
- These advancements are crucial for creating more effective PLGA formulations and enabling the production of affordable generic medications.
Poorly soluble drug molecules often have low bioavailability issues and absorption problems in the clinical setting. As the number of poorly soluble drugs increases from discovery, developing technologies to enhance their solubility, while also controlling their release is one of the many challenges facing the pharmaceutical industry today. Liquid crystalline systems, nanoparticulate or macro-matrix, self-assemble in the presence of an aqueous environment and can provide a solubility enhancement, while also controlling the drug release rate.
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