Publications by authors named "Gwangeon Sim"
Article Synopsis
- The study investigates HL156A, a potent AMPK activator, as a potential treatment for autosomal dominant polycystic kidney disease (ADPKD), which is commonly associated with cyst growth in kidneys.
- In laboratory tests, HL156A significantly inhibited the proliferation of renal cyst cells, showing a 25% reduction in cell viability at concentrations as low as 5 µM, while metformin had no effect.
- In mouse models, HL156A demonstrated its ability to effectively reduce both the number and size of cysts, improve kidney function, and modify key cellular signaling pathways related to cyst growth.
