Spontaneous Low-Frequency Cerebral Hemodynamics Oscillations in Restless Legs Syndrome with Periodic Limb Movements During Sleep: A Near-Infrared Spectroscopy Study.

Background And Purpose: Periodic limb movements (PLM) during sleep (PLMS) are associated with cortical and cardiovascular activation. Changes in cerebral hemodynamics caused by cortical activity can be measured using near-infrared spectroscopy (NIRS). We investigated oscillatory components of cerebral hemodynamics during PLM and different sleep stages in restless legs syndrome (RLS) patients with PLMS.

Regional and inter-regional theta oscillation during episodic novelty processing.

Recent event-related potential (ERP) and functional magnetic resonance imaging (fMRI) studies suggest that novelty processing may be involved in processes that recognize the meaning of a novel sound, during which widespread cortical regions including the right prefrontal cortex are engaged. However, it remains unclear how those cortical regions are functionally integrated during novelty processing. Because theta oscillation has been assumed to have a crucial role in memory operations, we examined local and inter-regional neural synchrony of theta band activity during novelty processing.

Topography of sensory symptoms in patients with drug-naïve restless legs syndrome.

Objectives: We aimed to describe the sensory topography of restless legs syndrome (RLS) sensory symptoms and to identify the relationship between topography and clinical variables.

Methods: Eighty adult patients with drug-naïve RLS who had symptoms for more than 1year were consecutively recruited. During face-to-face interviews using a structured paper and pencil questionnaire with all participants, we obtained clinical information and also marked the topography of RLS sensory symptoms on a specified body template, all of which were subsequently inputted into our in-house software.

Fronto-temporal interactions in the theta-band during auditory deviant processing.

Mismatch negativity (MMN) is a negative component of event-related potential (ERP) that reflects auditory deviant detection. Previous studies repeatedly suggested that MMN is generated by the fronto-temporal network. However, it is still unclear how the frontal and temporal areas interact.

Reduced Frontal P3a Amplitude in Migraine Patients during the Pain-Free Period.

Background And Purpose: Neuropsychological and neuroimaging studies both suggest that frontal lobe dysfunction is present in migraineurs. Since P3a abnormalities manifest in other diseases associated with attention problems, such as attention deficit hyperactivity disorder, we hypothesized that migraine patients have P3a abnormalities, particularly in the frontal region.

Methods: Event-related potentials were measured using a passive auditory oddball paradigm in 16 female migraineurs (aged 22.

Reduced neural synchrony in patients with restless legs syndrome during a visual oddball task.

Background: Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the legs. It has been reported that RLS patients show cognitive deficits, presumably due to hyperactivity causing loss of attention, or malfunctions in the frontal region resulting from sleep deprivation. However, the mechanism underlying cognitive deficits in RLS patients is mostly unknown.

Theta oscillation related to the auditory discrimination process in mismatch negativity: oddball versus control paradigm.

Background And Purpose: The aim of this study was to identify the mechanism underlying the auditory discriminatory process reflected in mismatch negativity (MMN), using time-frequency analysis of single-trial event-related potentials (ERPs).

Methods: Two auditory tones of different probabilities (oddball paradigm) and the same probability (control paradigm) were used. The average dynamic changes in amplitude were evaluated, and the in-phase consistency of the EEG spectrum at each frequency and time window across trials, event-related spectral perturbations (ERSPs), and inter-trial phase coherence (ITC) were computed.

Electrophysiologic disturbances during daytime in patients with restless legs syndrome: further evidence of cognitive dysfunction?

Backgrounds: It has been reported that patients with restless legs syndrome (RLS) may have cognitive deficit. The authors performed EEG and ERP analysis during daytime to identify electrophysiologic relations with cognitive dysfunction in unmedicated RLS patients.

Methods: Seventeen drug naive RLS patients (53.