Publications by authors named "Guzhanuer Ailiken"
TAS4464, a potent, selective small molecule NEDD8-activating enzyme (NAE) inhibitor, leads to inactivation of cullin-RING E3 ubiquitin ligases (CRLs) and consequent accumulations of its substrate proteins. Here, we investigated the antitumor properties and action mechanism of TAS4464 in acute myeloid leukemia (AML). TAS4464 induced apoptotic cell death in various AML cell lines.
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- BRG1 is a key ATPase in the SWI/SNF chromatin remodeling complex and is involved in forming neural crest cells by regulating genes related to epithelial-mesenchymal transition (EMT), particularly in relation to the protein CHD7.* -
- The study reveals that the splicing variant FIRΔexon2 interacts with BRG1 to post-transcriptionally regulate its expression, impacting cancer dynamics by suppressing Snai1, which is linked to preventing cancer invasion and metastasis.* -
- Analysis shown in this study indicates that FIRΔexon2 affects the splicing of FGF8 mRNA and its elevated presence in human gastric cancers suggests a significant role in tumor processes, undersc
Overexpression of alternative splicing of far upstream element binding protein 1 (FUBP1) interacting repressor (FIR; poly(U) binding splicing factor 60 [PUF60]) and cyclin E were detected in esophageal squamous cell carcinomas (ESCC). Accordingly, the expression of FBW7 was examined by which cyclin E is degraded as a substrate via the proteasome system. Expectedly, FBW7 expression was decreased significantly in ESCC.
View Article and Find Full Text PDFThe switch of pyruvate kinase (PK) M1 to PKM2 is pivotal for glucose metabolism in cancers. The PKM1/M2 shift is controlled by the alternative splicing of two mutually exclusive exons in the PKM gene. PKM1 is expressed in differentiated tissues, whereas PKM2 is expressed in cancer tissues.
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