[Clinical and functional disturbances in epilepsy patients with schizencephaly].

Objective: To study the features of diagnosing and predicting structural epilepsy in children with schizencephaly (SE) based on the analysis of clinical, electrophysiological and neuroimaging results.

Material And Methods: Fifteen patients with epilepsy and SE (seven boys and eight girls), aged from 3 months to 14 years, were examined.

Results: Unilateral SE was detected in ten patients (closed - in four, open - in six), bilateral open SE was detected in five patients.

[Diagnostic and prognostic significance of the level of IgM antibodies to myelin basic protein in children with traumatic brain injury].

Objective: To study the content of antibodies to the basic protein of myelin IgM in the blood of children with traumatic brain injury for a comprehensive assessment of the severity and prediction of outcomes of TBI.

Material And Methods: 81 children with traumatic brain injury (TBI) of varying severity and 29 children of the comparison group aged 2 months to 18 years were examined, in whom the content of IgM antibodies in blood plasma was determined.

Results: In groups of children with different severity of TBI, the average content of IgM antibodies in the blood is higher than in children of the comparison group, and the values of IgM antibodies correlate with the severity of TBI.

[Phenotypic and neuroimaging differentiation of polymicrogiry in children].

Aim: To study the results of the examination of children and to assess the degree of correlation of cortical disorders with phenotypic and neuroimaging characteristics of polymicrogyria (PMG).

Material And Methods: An analysis of disease history, neurological data, semiotics of epileptic seizures, neuroimaging and electrophysiological results was performed in 27 patients with PMG.

Results And Conclusion: Correlations between the prevalence of cortical malformation and the increased frequency of abnormalities in internal organs, stigma of dysembryogenesis, cognitive and motor disorders are shown.

[New opportunities in the optimization of epilepsy treatment in adolescents].

In the pubertal period, the most severe forms of childhood epilepsy persist and are modified; genetically determined syndromes, atypical for early and late age periods, make their debut. Hereditary predisposition, instability of homeostatic mechanisms, neuroendocrine restructuring at the age of puberty and the influence of factors contributing to the realization of a genetic defect lead to a long-term transformation of mediator systems and formation of epileptic activity in adolescents. The authors present common approaches in the treatment and characterization of the modern antiepileptic drug perampanel, which is highly effective in treatment of patients with resistant forms of epilepsy.

[Diagnosis and correction of cognitive impairment in preschool age children with epilepsy].

Objective: To study cognitive impairment and the efficacy of hopantenic acid (pantogam) in children, aged from 4 to 7 years, with epilepsy and cognitive impairment.

Material And Methods: The study included 40 children with epilepsy treated with pantogam (the main group) and 23 children with epilepsy who did not receive pantogam (the comparison group). All children were diagnosed with cryptogenic epilepsy and symptomatic epilepsy.

Characteristics of cognitive functions in children with epilepsy.

The aim of the present work was to study the causes and structure of interictal cognitive and emotionalpersonality impairments in children with different types of epilepsy. A total of 40 children were studied, aged from eight to 18 years. Symptomatic epilepsy was diagnosed in 31 patients (77.

[Peculiarities of cognitive functions in children with epilepsy].

A study aims at investigation of causes and structure of cognitive and emotional-personality interictal disturbances in children with different forms of epilepsy. Forty children, aged from 8 to 18 years, have been studied. Symptomatic epilepsy is diagnosed in 31 (77,5%) of patients, idiopathic epilepsy in 9 (22,5%) patients.

[Depakine in the therapy of epilepsy in children and adolescents].

The study included 642 patients, aged from 2 months to 18 years, who received different forms of depakine during the period from 2000 to 2006. Also the treatment with injection form of depakine was analyzed in 14 children. The drug was assessed in mono- and polytherapy.

[Analysis of blood hormone levels in boys of prepubertal and pubertal age with epilepsy treated with different antiepileptic drugs].

Thirty-nine boys with epilepsy, aged 8-17 years, and 61 sex- and age-matched controls have been examined. Changes of blood hormone levels were found in patients received carbamazepines, valproates, polytherapy as well as in non-treated patients. The increase of levels of progesterone, testosterone, FSH and LH, decrease of prolactin and estradiol levels and influence on thyroid gland hormones, as reflected by increasing of T4 and decreasing of T3 compared to carbamazepines, were found during the treatment with trileptal in the older group.