Publications by authors named "Guzel Gafiyatullina"
Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function and its role in the skeletal muscles remains underinvestigated.
View Article and Find Full Text PDFArticle Synopsis
- Selenoprotein P (SeP), linked to insulin resistance in type 2 diabetes, is increased in the liver under certain fatty acid conditions.
- Palmitic acid raises Selenop levels, while polyunsaturated fatty acids lower them; however, lauric acid (a medium-chain fatty acid) was shown to upregulate Selenop expression in hepatocytes.
- The study identifies that lauric acid enhances the binding of hepatic nuclear factor 4α (HNF4α) to the SELENOP promoter, which is crucial for the increased Selenop expression and suggests a role of SeP in mediating insulin signaling reduction impacted by medium-chain fatty acids.