Publications by authors named "Guyguy Kamwiziku"
Background: One year after the coronavirus disease 2019 (COVID-19) pandemic, the focus of attention has shifted to the emergence and spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs). The aim of the study was to assess the frequency of VOCs in patients followed for COVID-19 at Kinshasa university hospital (KUH) during the 3rd and 4th waves of the pandemic in Kinshasa. Hospital mortality was compared to that of the first two waves.
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- - Africa's Lake Tanganyika basin has been identified as a hotspot for cholera outbreaks.
- - From 2001 to 2020, Vibrio cholerae O1 strains were collected from the Democratic Republic of the Congo and split into 2 out of the 5 clades of the AFR10 sublineage.
- - One of these clades became the most common due to a mutation in the parC gene, which reduced its susceptibility to the antibiotic ciprofloxacin.
Background: Fungal infections are common causes of death and morbidity in those with advanced HIV infection. Data on access to diagnostic tests in Africa are scarce. We aimed to evaluate the diagnostic capacity for invasive fungal infections in advanced HIV disease in Africa.
View Article and Find Full Text PDFAmongst the treatable cause of blindness among young people, fungal keratitis ranks high. There are an estimated 1,051,787 to 1,480,916 eyes affected annually, with 8-11% of patients having to have the eye removed. Diagnosis requires a corneal scraping, direct microscopy and fungal culture with a large number of airborne fungi implicated.
View Article and Find Full Text PDFBackground: In symptomatic patients, the diagnostic approach of COVID-19 should be holistic. We aimed to evaluate the concordance between RT-PCR and serological tests (IgM/IgG), and identify the factors that best predict mortality (clinical stages or viral load).
Methods: The study included 242 patients referred to the University hospital of Kinshasa for suspected COVID-19, dyspnea or ARDS between June 1st, 2020 and August 02, 2020.
A literature review was conducted to assess the burden of serious fungal infections in the Democratic Republic of the Congo (DRC) (population 95,326,000). English and French publications were listed and analysed using PubMed/Medline, Google Scholar and the African Journals database. Publication dates spanning 1943-2020 were included in the scope of the review.
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- Four cholera outbreaks occurred in the Central African Republic between 1997 and 2016.
- The bacteria responsible were identified as Vibrio cholerae O1 serotype Inaba.
- These bacteria originated from three specific sublineages of the seventh pandemic El Tor strain, coming from West Africa and the African Great Lakes Region.