Publications by authors named "Guy Yalovitsky"
GH treatment in pediatric Down syndrome: a systematic review and mini meta-analysis.
Front Endocrinol (Lausanne)
May 2023
Objective: To analyze and determine the safety and efficacy of growth hormone (GH) treatment in Down syndrome (DS) pediatric patients and to weigh ethical aspects involved.
Design: Systematic review and mini meta-analysis of the literature.
Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022.
Objective: To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS).
Design: Systematic review and mini meta-analysis of the literature.
Methods: A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022.
Article Synopsis
- Children with pituitary hormone deficiency face risks of secondary adrenal insufficiency (AI), and a glucagon stimulation test (GST) is evaluated as a diagnostic tool compared to standard tests.* -
- A retrospective study of 120 pediatric patients assessed the GST's effectiveness in diagnosing AI but found it to have limited utility, particularly with lower sensitivity and specificity than the established low dose ACTH stimulation test (LDACTH).* -
- The findings indicate that the GST should be used cautiously for diagnosing secondary AI, as it showed high sensitivity at a higher cut-off but low specificity, suggesting it's not the best diagnostic option.*