Publications by authors named "Guy N"

In this study, a green synthesis method for synthesizing a novel nanocomposite (CuO/g-C₃N₄/Fe₃O₄) utilizing renewable dragon fruit peels as the primary raw material was developed. Hydrothermal and thermal decomposition techniques were used for nanocomposite synthesis. This nanocomposite was subsequently employed for the separation and preconcentration of Cd(II) from various environments, including food and water samples.

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This investigation aims to immobilize peroxidase onto 3-aminopropyltriethoxysilane (APTES)-functionalized MgFeO magnetic nanoparticles to increase enzyme stability, efficiency, and recyclability. The synthesized samples were analyzed using X-ray diffraction, Fourier transform infrared spectroscopy, Thermogravimetric analysis, Vibrating sample magnetometer, and Scanning electron microscopy. The free and immobilized peroxidase were examined against different pH and temperatures as well as storage time and reuse.

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Despite a range of methods used to promote modern agriculture with several outcomes, food quality and availability problems remain. This work aims to evaluate the effect of AM fungi inoculation on the growth, yield, nutritional, and antinutritional properties of 7 varieties of cassava. Growth characteristics, yields, rentability, nutritional, and antinutritional of tubers of each treatment were determined at harvest.

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Article Synopsis
  • HIV and malaria often occur together in the same regions, leading to co-infection that worsens the symptoms of both diseases, but the mechanisms behind this increase in severity are not well understood.
  • A pilot study in rhesus macaques treated with antiretroviral therapy (ART) aimed to explore the effects of co-infection, revealing persistent viral loads and decreased CD4+ T-cells despite treatment, along with signs of anemia and parasitemia.
  • The study also found that co-infection increased inflammatory markers and altered neutrophil behavior, suggesting that inflammation and gastrointestinal dysfunction could play key roles in the aggravated disease pathology seen in HIV and malaria co-infection.
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Caffeine consumption outcomes on Amyotrophic Lateral Sclerosis (ALS) including progression, survival and cognition remain poorly defined and may depend on its metabolization influenced by genetic variants. 378 ALS patients with a precise evaluation of their regular caffeine consumption were monitored as part of a prospective multicenter study. Demographic, clinical characteristics, functional disability as measured with revised ALS Functional Rating Scale (ALSFRS-R), cognitive deficits measured using Edinburgh Cognitive and Behavioural ALS Screen (ECAS), survival and riluzole treatment were recorded.

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Amyotrophic lateral sclerosis (ALS) is a rare multisystem neurodegenerative disease leading to death due to respiratory failure. Riluzole was the first disease modifying treatment approved in ALS. Randomized clinical trials showed a significant benefit of riluzole on survival in the months following randomization, with a good safety profile.

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What humans look at strongly determines what they see. We show that individual differences in the tendency to look at positive stimuli are stable across time and across contents, establishing gaze positivity preference as a perceptual trait that determines the amount of positively valence stimuli individuals select for visual processing. Furthermore, we show that patients with major depressive disorder exhibit consistently low positivity preference before treatment.

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A polyphasic taxonomic study was carried out on strain ES2, isolated from sediment of a wetland created to remediate acid drainage from a coal mine. The rod-shaped bacterium formed yellow/orange pigmented colonies and produced the pigment flexirubin. The 16S rRNA gene sequence results assigned the strain to , with 98.

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Amyotrophic lateral sclerosis (ALS) diagnosis relies on signs of progressive damage to both lower motoneuron (LMN), given by clinical examination and electromyography (EMG), and upper motoneuron (UMN), given by clinical examination only. Recognition of UMN involvement, however, is still difficult, so that diagnostic delay often remains too long. Shortening the time to clinical and genetic diagnosis is essential in order to provide accurate information to patients and families, avoid time-consuming investigations and for appropriate care management.

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A polyphasic taxonomic study was carried out on strain TSed Te1, isolated from sediment of a stream contaminated with acid drainage from a coal mine. The bacterium forms pink-pigmented colonies and has a rod-coccus growth cycle, which also includes some coryneform arrangements. This bacterium is capable of growing in the presence of up to 750 μg ml tellurite and 5000 μg ml selenite, reducing each to elemental form.

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Relationships between genes and amyotrophic lateral sclerosis (ALS) have been widely accepted since the first studies highlighting pathogenic mutations in the SOD1 gene 30years ago. Over the last three decades, scientific literature has clearly highlighted the central role played by genetic factors in the disease, in both clinics and pathophysiology, as well as in therapeutics. This implies that health professionals who care for patients with ALS are increasingly faced with patients and relatives eager to have answers to questions related to the role of genetic factors in the occurrence of the disease and the risk for their relatives to develop ALS.

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The many benefits of online research and the recent emergence of open-source eye-tracking libraries have sparked an interest in transferring time-consuming and expensive eye-tracking studies from the lab to the web. In the current study, we validate online webcam-based eye-tracking by conceptually replicating three robust eye-tracking studies (the cascade effect, n = 134, the novelty preference, n = 45, and the visual world paradigm, n = 32) online using the participant's webcam as eye-tracker with the WebGazer.js library.

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Humans rely heavily on the visual and oculomotor systems during social interactions. This study examined individual differences in gaze behavior in two types of face-to-face social interactions: a screen-based interview and a live interview. The study examined how stable these individual differences are across scenarios and how it relates to individuals' traits of social anxiety, autism, and neuroticism.

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When we explore our surroundings, we frequently move our gaze to collect visual information. Studies have extensively examined gaze behavior in response to different visual scenes. Here, we examined how differences in an individual's state may affect visual exploration, for example, following acute stress.

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Article Synopsis
  • Published studies on the impact of HFE polymorphisms on ALS (Amyotrophic Lateral Sclerosis) risk, phenotype, and survival remain inconclusive, prompting an evaluation of the p.H63D polymorphism in patients with -mutated ALS.
  • The study involved 183 -mutated ALS patients, assessing mutation severity and conducting survival analyses using methods like Kaplan-Meier and Cox proportional hazards modeling.
  • Results indicated that -mutated ALS patients with the p.H63D polymorphism had longer survival compared to non-carriers, regardless of factors like sex, age, and mutation severity, suggesting the polymorphism may influence disease progression.
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Humans differ in the amount of time they direct their gaze toward different types of stimuli. Individuals' preferences are known to be reliable and can predict various cognitive and affective processes. However, it remains unclear whether humans are aware of their visual gaze preferences and are able to report it.

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Objective: This retrospective (case-control) collaborative study evaluates tendon reflex recordings combined with transcranial magnetic stimulation motor evoked potentials recordings (T-MEPs) at lower limbs in amyotrophic lateral sclerosis (ALS).

Methods: T-MEPs were recorded in 97 ALS patients distinguished according to their patellar reflex briskness. Patients' electrophysiological data were compared with values measured in 60 control patients matched for age and height.

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Background: This case series reports on five consecutive patients who underwent image-guided transpedicular transthoracic microdiscectomy. The authors retrospectively reviewed five patients who had undergone Stealth image-guided transpedicular transthoracic microdiscectomy between 2015 and 2021.

Observations: Image guidance with O-arm verified critical anatomical landmarks in the setting of large central calcified and/or soft tissue disc prolapse.

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The Hsp90 chaperone is known to interact with a diverse array of client proteins. However, in every case examined, Hsp90 is also accompanied by a single or several co-chaperone proteins. One class of co-chaperone contains a tetratricopeptide repeat (TPR) domain that targets the co-chaperone to the C-terminal region of Hsp90.

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There is a range of differential diagnoses for intramedullary lesions of the conus medullaris, both neoplastic and non-neoplastic. There is a limited role for surgery in a large proportion of these diagnoses, and operative risks can outweigh any benefits of surgery. Here a case is presented of a patient referred to a neurosurgical center for a biopsy of a presumed neoplastic conus tumor.

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Acute stress has been found to elicit pro-social, anti-social or null responses in humans. The causes for these contradicting findings are currently poorly understood, and may rise from subjects' characteristics, such as sex or hormonal status, as well as stimuli-based traits, such as group membership. In the current study, 120 subjects performed either the Trier Social Stress Test or a control (non-stress inducing) condition, followed by ranking displayed faces according to several attributes (e.

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How does acute stress influence the degree to which we cooperate with others? Research on the effects of stress on social decision-making is guided by two seemingly contrasting theories. Acute stress may trigger a Fight-or-Flight response, manifested by increased anxiety, and more egocentric or selfish behavior. Alternatively, according to the Tend-and-Befriend model, acute stress may induce affiliative behaviors, marked by increased prosociality in an effort to seek and receive social support and protection.

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Background And Objective: variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands.

Methods: was analyzed in 860 probands with hemiplegic migraine, and variations were identified in 30 probands.

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Objective: To evaluate the relevance of transcranial magnetic stimulation (TMS) using triple stimulation technique (TST) to assess corticospinal function in amyotrophic lateral sclerosis (ALS) in a large-scale multicenter study.

Methods: Six ALS centers performed TST and conventional TMS in upper limbs in 98 ALS patients during their first visit to the center. Clinical evaluation of patients included the revised ALS Functional Rating Scale (ALSFRS-R) and upper motor neuron (UMN) score.

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Article Synopsis
  • This study aimed to investigate how the familial clustering and symptoms of ALS (amyotrophic lateral sclerosis) cases could help identify the disease's genetic causes.
  • Researchers analyzed genetic mutations in 235 French families with familial ALS to find connections between genealogy and the disease's characteristics.
  • Findings indicated that specific genetic mutations were linked to the number of affected family generations, suggesting that understanding family history and symptoms could guide targeted genetic testing for ALS.
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