Hepatocellular carcinoma metastatic to the mandible.

We describe the case of a 55-year-old man with known multifocal hepatocellular carcinoma (HCC) who presented with a painful mandibular mass. Fine-needle aspiration cytology of the mass revealed the presence of bile canaliculi and bile formation, an extremely rare finding. Findings on immunoperoxidase staining of the aspirate were consistent with an HCC.

Temporal bone verrucous carcinoma: outcomes and treatment controversy.

Objectives: Verrucous carcinoma is a rare tumor that presents in the head and neck with the most common sites in the larynx and oral cavity. Fourteen cases of verrucous carcinoma of the temporal bone have been described in the literature; this study aims to examine treatment outcomes and discuss the controversy surrounding postoperative radiation.

Study Design: A literature review along with individual case report in the setting of a tertiary care medical center.

Temporal bone verrucous carcinoma: outcomes and treatment controversy.

Verrucous carcinoma is a rare tumor that presents in the head and neck with the most common sites being the oral cavity and larynx. Fourteen cases of verrucous carcinoma of the temporal bone have been described in literature; this study aims to examine treatment outcomes and discuss the controversy surrounding postoperative radiation. The study design included a literature review along with individual case report in the setting of a tertiary care medical center.

Adjuvant external-beam radiotherapy in patients with high-risk well-differentiated thyroid cancer.

The role of adjuvant external-beam radiation therapy (EBRT) in well-differentiated thyroid cancer is not well delineated. Many clinicians rely solely on iodine 131 (131I) to destroy thyroid remnants following thyroidectomy. However, the lesser uptake of isotope in tumor cells suggests that 131I alone may not be sufficient to eradicate microscopic residual disease when no gross thyroid tissue remains.

Reirradiation after salvage surgery and microvascular free flap reconstruction for recurrent head and neck carcinoma.

Objective: To evaluate the outcome and complications of reirradiation of recurrent head and neck cancer after salvage surgery and microvascular reconstruction.

Study Design: Retrospective.

Subjects And Methods: Twelve patients underwent salvage surgery with microvascular reconstruction for recurrent or second primary head and neck cancer in a previously irradiated field.

Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy.

Objective: To evaluate quality of life issues in patients with laryngeal cancer after treatment with either chemoradiation or total laryngectomy and radiation therapy.

Methods: Forty-nine patients with a history of stage II-IV laryngeal squamous cell carcinoma treated primarily with either chemoradiation or by total laryngectomy with postoperative radiation completed the University of Washington Quality of Life instrument, version 4. Patients were identified on a volunteer basis in an academic university head and neck clinic setting.

Early nodal response as a predictor for necessity of functional neck dissection after chemoradiation.

Purpose: Chemoradiation is increasingly becoming the standard of care for node-positive squamous cell cancer of the head and neck. Response to chemoradiation for clinically node-positive disease in the neck is often difficult to ascertain because clinical response may or may not be predictive of pathological response. This often leads to uncertainty about the necessity of a functional neck dissection after chemoradiation.

Sinonasal undifferentiated carcinoma: case series and literature review.

Purpose: The purpose of this study was to understand the natural history and progression of sinonasal undifferentiated carcinoma (SNUC) to establish optimal management guidelines. Methods and materials We analyzed 8 consecutively treated patients diagnosed with SNUC between 1995 and 2002 at UCLA Medical Center. Staging was classified by the Kadish System with 7 patients presenting at stage C and 1 patient with stage B disease.

Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma.

Background: Desmoplastic malignant melanoma (DMM) is a rare variant of malignant melanoma with high local recurrence rate after surgical excision. We performed a retrospective review to address the role of radiation therapy in local control of this tumor.

Methods: Between 1976 and 1997, 44 patients with the pathologic diagnosis of DMM were registered at our tumor registry.

The role of radiation in the treatment of advanced juvenile angiofibroma.

Objectives/hypothesis: To demonstrate the efficacy of external beam radiation therapy as a primary treatment modality for the management of patients with advanced juvenile nasopharyngeal angiofibroma (JNA).

Study Design: Retrospective chart review.

Methods: The medical records of 130 patients with the diagnosis of JNA seen at UCLA Medical Center over a 41-year period (1960-2000) were retrospectively reviewed.