Publications by authors named "Guy Journo"
Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure episome maintenance, the latency protein LANA tethers the viral episomes to the cell chromosomes during cell division.
View Article and Find Full Text PDFKaposi's sarcoma-associated herpesvirus (KSHV), also familiar as human herpesvirus 8 (HHV-8), is one of the well-known human cancer-causing viruses. KSHV was originally discovered by its association with Kaposi's sarcoma (KS), a common AIDS-related neoplasia. Additionally, KSHV is associated with two B-lymphocyte disorders; primary effusion lymphoma (PEL) and Multicentric Castlemans Disease (MCD).
View Article and Find Full Text PDFKaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is a gamma herpesvirus associated with several human malignancies. Transposable elements (TEs) are ubiquitous in eukaryotic genomes, occupying about 45% of the human genome. TEs have been linked with a variety of disorders and malignancies, though the precise nature of their contribution to many of them has yet to be elucidated.
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- - Kaposi's sarcoma (KS) is a type of cancer associated with AIDS, caused by the KS herpesvirus (KSHV/HHV-8), which leads to tumor formation through both viral gene expression and changes in the host’s genetics and epigenetics.
- - Research using mouse models indicates that while the loss of KSHV before tumor formation prevents tumor growth, tumors formed from cells that lose KSHV later can still be cancerous, suggesting that the virus may induce lasting genetic changes that lead to cancer.
- - RNA-sequencing and mutations analyses show that KSHV-positive tumors have a pattern of gene regulation and mutations that differs from KSHV-negative tumors, indicating that pre-existing host mutations may
Epstein-Barr virus (EBV) is associated with a variety of tumors and nonmalignant conditions. Latent EBV genomes in cells, including tumor cells, are often CpG methylated, whereas virion DNA is not CpG methylated. We demonstrate that methyl CpG binding magnetic beads can be used to fractionate among sources of EBV DNA (DNA extracted from laboratory-purified virions vs DNA extracted from latently infected cell lines).
View Article and Find Full Text PDFKaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is a gammaherpesvirus associated with several human malignancies. DNA methylation at CpG dinucleotides is an epigenetic mark dysregulated in many cancer types and in KSHV-infected cells. Several previous studies have analyzed in detail the CpG methylation of the KSHV episomal genomes, but little is known about the impact of KSHV on the human genome.
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