Publications by authors named "Guy G James"
Article Synopsis
- The enzyme CYP121 is a promising drug target for combating antibiotic-resistant Mycobacterium tuberculosis, and a triazol-1-yl phenol compound was found to effectively bind to it through various biophysical tests.*
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- After improving the binding affinity of the initial compound 100-fold, researchers deconstructed it to identify key structural features and optimize new lead compounds with enhanced properties.*
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- By strategically adding a metal-binding element to potent scaffolds, they developed highly effective CYP121 inhibitors with exceptional selectivity, utilizing advanced techniques like X-ray crystallography for further insights into drug design.*
