An electrochemical generator for the continual supply of Bi from Ac for use in targeted alpha therapy applications.

Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of Ac. Radionuclide generators employ longer lived "parent" radionuclides to routinely supply shorter-lived "daughter" radionuclides. The traditional Ac/Bi radiochemical generator relies on an organic cation exchange resin where Ac binds to the resin and Bi is routinely eluted.

1,10-Phenanthroline and non-symmetrical 1,3,5-triazine dipicolinamide-based ligands for group actinide extraction.

The synthesis and evaluation of new extractants for spent nuclear fuel reprocessing are described. New bitopic ligands constituted of phenanthroline and 1,3,5-triazine cores functionalized by picolinamide groups were designed. Synthetic routes were investigated and optimized to obtain twelve new polyaza-heterocyclic ligands.