Publications by authors named "Guy D Lester"
Exercise-induced Pulmonary Hemorrhage: Is It Important and Can It Be Prevented?
Vet Clin North Am Equine Pract
August 2019
Exercise-induced pulmonary hemorrhage (EIPH) occurs commonly in horses undergoing strenuous exercise. Reported risk factors include racing in cold temperatures and wearing of bar shoes. In horses with documented moderate to severe EIPH, increasing the interval between races and adopting a negative race pace strategy may reduce the severity of EIPH in subsequent races.
View Article and Find Full Text PDFObjective: To determine the agreement of invasive blood pressure measured in the facial, metatarsal and carotid arteries, and evaluate the effects of two haemodynamic conditions on agreement.
Study Design: Prospective randomized study.
Animals: A group of eight horses aged 7 (4-23) years with a body weight of 493 ± 33 kg.
Objective: To determine agreement between invasive blood pressures measured in three peripheral arteries in anaesthetized horses undergoing elective surgery.
Study Design: Prospective balanced incomplete block design.
Animals: A total of 18 client-owned horses.
OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.
View Article and Find Full Text PDFObjective: To determine effects of leukotriene (LT) C(4) on ion transport across equine tracheal epithelium. Sample-Tracheal epithelium from cadavers of 24 horses considered free of respiratory tract disease.
Procedures: Mucosae were mounted into Ussing chambers, and short-circuit current (I(sc)) was monitored over time.
Objective: To test single cycle to failure tensile strength characteristics of 6 suture material-pattern combinations in equine superficial digital flexor (SDF) tenorrhaphy, specifically to compare a 10-strand modification of the Savage core suture technique with the 3-loop pulley technique.
Study Design: Ex vivo mechanical experiment comparing 3 different suture patterns with 2 different materials.
Sample Population: Forelimb and hindlimb SDF tendons (n=48) harvested from adult Thoroughbred and Standardbred horses of mixed age and gender.
Objective: To compare secretory responses to prostaglandin (PG) E(2) in mucosa obtained from the proximal and distal portions of the colon of dogs.
Sample: Colonic mucosa from cadavers of 18 clinically normal adult dogs.
Procedures: Short-circuit current (I(SC)) and maximum change in I(SC) (ΔI(sc)) in response to administration of 1μM PGE(2) were measured across mucosa obtained from the proximal and distal portions of the colon.
Objective: To identify factors associated with short-term survival in bacteremic neonatal foals, evaluate the racing performance of Thoroughbred survivors, and evaluate changes in causative organisms and their antimicrobial susceptibility.
Design: Retrospective case series.
Animals: 423 bacteremic foals.
Objective: To compare the effects of oral administration of omeprazole and ranitidine on gastric squamous ulceration in Thoroughbreds in race training.
Design: Modified crossover study.
Animals: 60 Thoroughbreds in race training with gastric squamous mucosal ulceration.
Article Synopsis
- Managing an immature foal can be quite challenging, even for seasoned veterinarians, due to complications that may affect multiple body systems like musculoskeletal, respiratory, and gastrointestinal.
- It's essential to inform the owner about the potential short-term and long-term survival rates, expected costs, and possible complications before starting treatment.
- Creating an accurate prognosis requires an understanding of normal foal maturation and the various factors that influence this development.
Objective: To determine factors associated with development of postoperative ileus (POI) in horses undergoing surgery for colic.
Design: Prospective case-control study.
Animals: 251 horses undergoing colic surgery, of which 47 developed POI.
The aim of this retrospective study was to determine the clinical usefulness of thoracic ultrasonography compared to thoracic radiography in evaluation of Rhodococcus equi pneumonia. Criteria for patient inclusion in this study were: (1) isolation of R. equi from transtracheal aspirate, (2) radiographic evaluation of the pulmonary parenchyma, and (3) sonographic evaluation of the pulmonary parenchyma.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze clinical findings and outcomes in 46 horses diagnosed with West Nile virus (WNV) encephalomyelitis, revealing higher incidence in males and common symptoms like fever, weakness, and muscle fasciculations.
- Diagnostic tests confirmed WNV in most cases, with a 30% mortality rate; many horses that survived faced long-term neurological deficits.
- The research highlighted the importance of diagnostic testing and supportive treatment, noting that while recovery is generally positive, not all horses returned to normal functionality after discharge.
Objective: To evaluate the reliability of a method for inducing colic via small intestinal distention in horses and to examine the analgesic potential of bilateral electroacupuncture (EAP) at the Guan-yuan-shu (similar to BL21) acupoint.
Animals: 5 healthy adult horses, each with a gastric cannula.
Procedure: A polyester balloon connected to an electronic barostat was introduced into the duodenum via the gastric cannula.
Objective: To determine the effect of pH with or without pepsin or taurocholic acid on the bioelectric properties of gastric squamous mucosa in horses.
Sample Population: Gastric tissues obtained from 16 adult horses that did not have evidence of gastric disease.
Procedure: Bioelectric properties of squamous mucosa were determined, using modified Ussing chambers.