Sampling of the anterior apical region results in increased cancer detection and upgrading in transrectal repeat saturation biopsy of the prostate.

Objective: To evaluate whether biopsy cores taken via a transrectal approach from the anterior apical region of the prostate in a repeat-biopsy population can result in an increased overall cancer detection rate and in more accurate assessment of the Gleason score.

Patients And Methods: The study was a prospective, randomised (end-fire vs side-fire ultrasound probe) evaluation of 288 men by repeat transrectal saturation biopsy with 28 cores taken from the transition zone, base, mid-lobar, anterior and the anterior apical region located ventro-laterally to the urethra of the peripheral zone.

Results: The overall prostate cancer detection rate was 44.

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

Background: Patients with prostate cancer may present with metastatic or recurrent disease despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the bone has limited repeated sampling of tumor deposits. Hence, considerably less is understood about this lethal metastatic disease, as it is not commonly studied.

Critical assessment of preoperative urinary prostate cancer antigen 3 on the accuracy of prostate cancer staging.

Background: Knowledge about the staging significance of the prostate cancer antigen 3 (PCA3) score to better identify pathologic features after radical prostatectomy (RP) is limited and controversial.

Objective: Our aim was to study the clinical staging significance of PCA3 to identify pathologic favorable and/or unfavorable features in the RP specimen.

Design, Setting, And Participants: Complete retrospective clinical and pathologic data of consecutive men who had undergone RP from three tertiary referral centers including preoperative PCA3 scores (n=305) and computer-assisted planimetrically measured tumor volume data (n=160) were available.

Analysis of 274 Omniflow Vascular Prostheses implanted over an eight-year period.

Background: Polytetrafluoroethylene (PTFE), dacron, and, more recently, collagen prostheses are finding increasing use for femoropopliteal reconstruction when a suitable vein is not available. The main factors to be considered when choosing a prosthesis are patency, susceptibility to infection and formation of aneurysms.

Methods: Sheep collagen prostheses were implanted on 274 occasions in the femoropopliteal or crural regions.

[Results of surgical treatment of pregnancy-associated pelvic vein thrombosis].

We report the results of surgical treatment of iliofemoral vein thrombosis in 49 pregnant women in a seven years period. The patients mean age was 26.5 years (range 18-41 years).

Paragangliomas of the carotid bifurcation: oncological aspects of vascular surgery.

The present study reviews in concise form the past 12 years of our clinical experience with paragangliomas of the carotid body. Every aspect of the anatomical, histological and biological and biological behaviour of paragangliomas of the carotid body has been recorded in order to be able to define better surgical management and the clinical prognosis. In addition to the conventional histological methods of investigation we also applied immunohistochemistry and made use of electron microscopy.

[Indications and outcome of simultaneous operation of carotid stenoses and stenosing coronary arteriosclerosis].

Between 1986 and September 1995 100 patients with carotid artery stenosis and coronary artery disease underwent combined carotid endarterectomy and CABG. The indications for carotid endarterctomy were transient neurological events in 38 patients and in 62 cases high-grade asymptomatic carotid artery stenosis. The surgical procedures were always performed by a vascular and a cardiac surgical team.

[Femoropopliteal vascular replacement: vein, ePTFE or ovine collagen?].

In an eight year-period from 1988 to 1995 653 femoropopliteal and femorocrural bypasses were performed. 347 above-knee reconstructions 206 below-knee reconstructions and at last 100 femorocrural bypasses were analysed. The cumulative patency rate after a follow up of three years for above-knee vein bypasses was 90%, patency rate for PTFE grafts in the same period was 52%, for ovine collagen grafts 56%.

Diagnosis and treatment of carotid body tumors.

Carotid body tumors are rare although they must always remain part of the differential diagnosis of a neck mass. Sonography as the screening method of choice followed by angiography determines the diagnosis. In 11 patients 12 carotid body tumors were extirpated.

[Jugulotympanic paraganglioma].

A case is described of a jugulotympanic paraganglioma in a 64-year-old woman with extentions down the jugular vein to the clavicle and penetration of the cerebellar fossa. The symptoms, differential diagnosis, therapy and prognosis are discussed on the basis of this case report and compared with the literature. The importance of radiological investigation (e.

[Iatrogenic vascular injuries in childhood].

From 1973 until 1982, 616 arterial angiographies were done in children. 13 thromboses in the early state could be diagnosed and were treated surgically. Five times a haemorrhage after angiography made surgical intervention necessary.

[Surgical treatment of acute pelvic vein thrombosis].

From 1974 to 1980 77 patients underwent thrombectomy for thrombosis of their iliac or leg veins. 45 patients became symptom-free. The mean age of the patients (mostly females) came up to 43 years, the oldest was 82, the youngest 13 years of age.

[Displacement of electrodes in pacemaker patients (author's transl)].

The implantation of special electrodes is indicated by right ventricular dilatation and especially by electrode displacement. For this purpose the MIP 2000 has been used with good results. It is the electrode preferred currently, but it may be replaced in future by the screw electrode which is now being clinically tested.