[Characteristics of oxidative stress in mental maladaptation].

Changes in the balance of pro and antioxidant systems were studied in persons in state of mental maladaptation, developed under the influence of emotional stress. Activation of lipid peroxidation has been revealed associated with increase of amount of malondialdehyde in erythrocytes and blood serum in persons surveyed. Activity of catalase and glutathione peroxidase in erythrocytes in persons in state of mental stress was increased and glutathione preductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase has been reliably reduced as compared with group of healthy people.

[Genetic epidemiology of schizophrenia in the population of Tomsk Oblast. Dependence of parameters of the occurrence of schizophrenia among relatives on the method of proband sample formation].

The program of genetic-epidemiological study of schizophrenia in five districts of the Tomsk region is presented. According to standardized methods, 610 diagnosed patients (epidemiological register) were examined, 74.1% of them being at random registered as probands (452 families of the epidemiological sample).