[The system stress-limiting action of mexidol in chronic cerebral ischemia].

Objective: To clarify the mechanisms of the action of anti-stress antioxidant agent (mexidol) in patients with chronic cerebral ischemia.

Material And Methods: Sixty-seven patients with chronic cerebral ischemia (TE stage II),48 women and 19 men, mean age 48.2 years, were examined.

[Ophthalmic manifestations of Huntington's disease].

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene. The whole nervous system, including visual analyzer, is involved in the pathogenesis of the disease. Various ocular sings can be found in both preclinical and clinical stages of HD.

[Gluten migraine].

Objective: to study the prevalence of migraine among patients with celiac disease (CD) and clinical features of «gluten migraine» syndrome and to assess the efficacy of gluten diet in its treatment.

Material And Methods: Authors examined 200 CD patients (main group) and 100 patients with reflux esophagitis and without CD (control group). All patients fulfilled the headache diary during three months before the diagnosis of migraine was made and six months during gluten diet.

[Genetic aspects of migraine].

Migraine is a common disease characterized by severe headache with nausea, vomiting and hypersensitivity to sounds, light, smell. Neurological symptoms during aura period develop in 25% of patients. Genes responsible for migraine development have been identified.

[Polyneuropathy of thin fibers].

Polyneuropathy of thin fibers (PTF) is a disorder with selective damage of Aδ- and C-fibers. Having a skin biopsy the SFN became visible. In the article there are data on the pathogenesis, clinics and diagnostics of the PTF.

[Immunohistochemical examination of skin biopsy specimens with calculation of C fibers in the diagnosis of polyneuropathy].

The paper discusses the anatomy of innervation of the skin, the epidermis and dermis in particular, which are related to pain, the markers of skin nerves and cells. It gives data on the diagnosis of fine unmyelinated fibers, by immunohistochemically examining skin biopsy specimens. The paper also describes the morphometry of skin nerves: intraepidermal nerve fibers, dermal nerve fibers, and autonomic nerve fibers.

[An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia].

Objective: To study an effect of nonspecific cytoprotective therapy on clinical manifestations, disease course and indicators of stress system in patients with different stages of chronic cerebral ischemia (CCI).

Material And Methods: Authors examined 266 patients with CCI, aged from 35 to 55 years. The patients received basic and nonspecific cytoprotective therapy.

[The results of Russian multicenter open-label observational study of the efficacy and safety of мelaxen (melatonin) for the treatment of disordered sleep in patients with chronic cerebral ischemia].

The results of the multicenter open-label observational study of the efficacy and safety of the Melaxen (melatonin) for the treatment of disordered sleep in patients with chronic cerebral ischemia are presented. 2062 patients were studied with the use of subjective psychometric scales: subjective sleep characteristics scale, sleep apnea screening questionnaire, Epworth sleepiness scale, hospital anxiety and depression scale. Mean age of patients was 55.

[Intensive glycemia control in the first day of the acute cerebral blood flow disturbance in patients with diabetes mellitus type 2].

Forty-seven patients with cerebral stroke and diabetes mellitus type 2 were included in the study. To maintain the target values of glycemia on the level 7.8-10.

[Possibilities of preventive treatment of Alzheimer's disease: results of the 3-year open prospective comparative study on efficacy and safety of the course therapy with cerebrolysin and cavinton in elderly patients with the syndrome of mild cognitive impairment].

The study was conducted in 3 Russian centers (Moscow, St. Petersburg and Nizhniy Novgorod). The total sample included 110 patients whose mental state met the definition of <> (MCI).

Effect of antioxidant therapy on glutathione system of erythrocytes in chronic brain ischemia.

We studied the effect of antioxidant therapy on the state of glutathione system in erythrocytes in patients with stage 1, 2, and 3 circulatory encephalopathy treated with antioxidant cytoflavin against the background of basic therapy (kavinton and pyracetam). It was demonstrated that the response of the erythrocyte glutathione system to antioxidant therapy was quantitatively and qualitatively different at different stages of cerebrovascular failure, which was related to changes in the glutathione system during the development of chronic cerebral ischemia. Endogenous reserve of the antioxidant defense system should be taken into account when prescribing antioxidant therapy; the glutathione system can be a marker of this reserve.

[Tanakan (EGb 761) in the therapy of mild cognitive impairment].

Mild Cognitive Impairment (MCI) means cognitive deterioration not yet causing disability or dementia. Aged patients with MCI constitute a group of high risk for Alzheimer disease and other types of dementia. Currently, there is no generally adopted approach to MCI management but medications with neuroprotective properties are presumed to be the most perspective.

[The influence of ceruloplasmin on the rat neocortical ultrastructure in circulatory hypoxia].

Diffuse cerebral ischemia and circulatory hypoxia were modeled by carotid arteries occlusion in 40 white Wistar male rats. The changes of microcirculation bed and neurons of the sensomotor cortical area in hypoxia, preventive and therapeutic regimes of ceruloplasmin injections were compared to the neocortex state of intact rats. The changes of the neocortical ultrastructure established by electron microscopy were characteristic of hypoxic lesions described earlier in the literature.

[Efficacy of combined kineso- and psychotherapy in the treatment of patients with migraine].

The study aimed at determining the efficacy of combined kineso- and psychotherapy in the treatment of patients with migraine in between-attacks periods. Forty-one patients with migraine (3 males, 38 females, mean age 38.2 +/- 1.

[Clinical and neurophysiological features and outcome prognosis criteria of Guillain-Barre syndrome in children].

Clinical and electroneuromyographical (ENMG) study of 24 children with Guillain-Barre syndrome (GBS) was conducted. Using ENMG, axonal and demyelinating GBS variants differing by course and rehabilitation time were distinguished. To predict a development of bulbar and respiratory disorders and to evaluate their severity and duration, diaphragm and adductive nerves conduction was investigated.

[Neurophysiological criteria for the diagnosis and prognosis of facial nerve neuropathy in children].

Electromyography bindings of blink reflex, visual and acoustic evoked potentials have been studied in 35 children with facial nerve neuropathy (FNN), 20 children with FNN being manifested for the first time and 15 children being affected with recurrent type. Blink reflex analysis in FNN has revealed trifacial and controlateral facial nerve pathology in 10-20% cases. Factors essentional for rehabilitation and development of complications were the following: (1) duration of conduction block along trigeminis-facial nerve arch, (2) conduction block association, according to the blink reflex, with the absence of M-response in direct facial nerve stimulation, (3) a coefficient of M-response amplitude ratio on affected and intact sides, (4) P100 latency disturbance and its wave like rehabilitation during 4-6 months.